PMID: 11323117Apr 27, 2001Paper

Expression of p-glycoprotein is associated with that of multidrug resistance protein 1 (MRP1) in the vestibular labyrinth and endolymphatic sac of the guinea pig

Neuroscience Letters
T SaitoH Saito

Abstract

Expression of p-glycoprotein (p-gp) and multidrug resistance protein 1 (MRP1) was detected in the vestibular labyrinth and endolymphatic sac (ES) of the guinea pig by immunohistochemical staining using anti-p-gp monoclonal antibody (mAb) C219 and anti-MRP mAb MRPr1. P-gp was detected in capillary endothelial cells of the crista ampullaris, utricle, saccule and ES. MRP1 was detected in the epithelial lining of the crista ampullaris, utricle, saccule, and epithelial cells of the ES. Since p-gp and MRP1 act as extrusion pumps, they may coordinate with each other in vestibular organs and ES and play an important role in the blood-labyrinth barrier.

References

Jan 1, 1992·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·H J AltermattJ Laissue
Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·C Cordon-CardoJ R Bertino
Dec 1, 1989·Journal of Neurochemistry·R Spector
Mar 1, 1981·The Annals of Otology, Rhinology, and Laryngology·S K JuhnS Prado
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·V V RaoD Piwnica-Worms
Jun 30, 2000·Biochemical Pharmacology·F Van BambekeP M Tulkens
Aug 17, 2000·Journal of the National Cancer Institute·P BorstJ Wijnholds

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Citations

Aug 12, 2015·International Journal of Pharmaceutics·Naila El KechaiAmélie Bochot
Jul 11, 2014·HNO·A Liebau, S K Plontke
Jun 23, 2019·Human Molecular Genetics·Ryotaro OmichiRichard J H Smith
Jul 6, 2019·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Meng LiYong Feng

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