Expression of P-selectin and intercellular adhesion molecule-1 in human brain after focal infarction or cardiac arrest

Neuropathology and Applied Neurobiology
S Love, R Barber

Abstract

Data from experimental studies indicate that acute inflammation contributes to ischaemic brain damage. Tethering of neutrophils to brain endothelium is mediated by selectins, and subsequent adhesion and migration by endothelial intercellular adhesion molecule-1 (ICAM-1) and neutrophil CD18. In experimental studies of ischaemia-reperfusion injury, brain damage has been ameliorated by administration of antibodies to these adhesion molecules. We studied the expression of P-selectin and ICAM-1 in sections of brain from patients who had experienced cardiac arrest or focal brain infarction, and who died 3.5 h to 9 days later. Endothelial immunopositivity for both adhesion molecules was maximal at about 2-3 days then declined. Between 1 day and 3 days, P-selectin was also detected on platelets in blood vessels within infarcted tissue. Within infarcts, but not sections of brain from cardiac arrest patients, P-selectin and ICAM-1 were again detectable at 1 week, when hyperplastic endothelial cells were labelled in capillaries in and immediately adjacent to the infarcted tissue. The finding that P-selectin and ICAM-1 are upregulated within focally infarcted brain tissue supports the concept that blocking neutrophil adhesion may be of ben...Continue Reading

References

Dec 14, 1995·The New England Journal of Medicine·UNKNOWN National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group
Jan 1, 1994·Stroke; a Journal of Cerebral Circulation·Y OkadaG J del Zoppo
Nov 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R L ZhangA Manning
Jul 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M ChoppJ Prostak
Jan 1, 1997·Brain Pathology·G Turner
Nov 25, 1997·Annals of the New York Academy of Sciences·G Z FeuersteinF C Barone
Mar 3, 1998·Neurosurgery·S HolminT Mathiesen
Mar 4, 1998·Current Opinion in Neurology·K J Becker
Nov 14, 1998·Journal of Neurotrauma·M J WhalenP D Adelson
Dec 16, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K KitagawaT Yanagihara
Jan 8, 1999·Stroke; a Journal of Cerebral Circulation·S G SorianoT N Mayadas
Apr 24, 1999·Neuropathology and Applied Neurobiology·S LoveG K Wilcock
May 7, 1999·Stroke; a Journal of Cerebral Circulation·C J PrestigiacomoD J Pinsky
May 18, 1999·Neuroscience Letters·H SuzukiK Abe
Aug 24, 1999·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·A BlannG Y Lip
Mar 29, 2000·Neuropathology and Applied Neurobiology·S LoveG K Wilcock

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Citations

May 12, 2012·Der Anaesthesist·A SchneiderP Teschendorf
Jun 10, 2003·Current Atherosclerosis Reports·Kiat T TanAndrew D Blann
Jan 22, 2003·Journal of Immunological Methods·Carlo Laudanna, Gabriela Constantin
Nov 4, 2005·Biological Research for Nursing·Marguerite T Littleton-KearneyPatricia D Hurn
Mar 5, 2010·Blood·Peter ThorntonNancy J Rothwell
Nov 6, 2013·Immunotherapy·Stefano Angiari, Gabriela Constantin
Jun 28, 2003·Proceedings of the National Academy of Sciences of the United States of America·Pia KivisäkkRichard M Ransohoff
Oct 27, 2010·Translational Stroke Research·Muzamil Ahmad, Steven H Graham
May 25, 2007·Archives of Physiology and Biochemistry·Alexander V OvechkinAndrew M Roberts
Oct 12, 2014·Critical Care : the Official Journal of the Critical Care Forum·Laurens BisschopsCornelia Hoedemaekers
Nov 7, 2015·Seminars in Cell & Developmental Biology·Kevin G BurfeindDaniel L Marks
Aug 1, 2006·Neurologic Clinics·Robert SkinnerNancy Rothwell
Jul 16, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E C Adam, P M Lackie
Jan 3, 2013·Annals of Neurology·Richard Daneman
Apr 25, 2009·Immunology and Allergy Clinics of North America·Robert SkinnerNancy Rothwell
Aug 1, 2016·Oral and Maxillofacial Surgery Clinics of North America·Zahid H BajwaSteven J Scrivani
Aug 6, 2008·Critical Care Medicine·Clifton W CallawayMelissa J McMichael
Apr 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Laura PiccioGabriela Constantin
May 3, 2019·Nature Communications·Luc BertrandMichal Toborek
Feb 13, 2003·Journal of Neuropathology and Experimental Neurology·Gary H Danton, W Dalton Dietrich

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