PMID: 11923556Mar 30, 2002Paper

Expression of p21 in SV40 large T antigen positive human pleural mesothelioma: relationship with survival

Thorax
Alfonso BaldiM G Paggi

Abstract

Mesothelioma is the most commonly occurring primary pleural neoplasm. Several studies have documented an increase in the incidence of this malignancy during the last decades. Although the association between asbestos exposure and development of mesothelioma is generally accepted, the exact mechanism of carcinogenesis is unknown. Recently, Simian virus 40 large T antigen (SV40 Tag) expression has been detected in pleural mesothelioma. The ability of SV40 oncoproteins to inactivate p53 and retinoblastoma tumour suppressor proteins has been proposed as an important step in the pathogenesis of human mesothelioma. To obtain a better understanding of the molecular mechanisms of the pathogenesis of mesothelioma, the expression of the cell cycle inhibitor p21(WAF1/CIP1) (p21), a downstream target of p53, was evaluated immunohistochemically in a group of 29 mesothelioma specimens already characterised for the presence of SV40 Tag sequences. Statistical analysis did not reveal any correlation between p21 expression and histopathological type of mesothelioma using the kappa(2) test (p=0.577). A significant positive relationship was found between p21 expression level and the patients' overall survival according to the Kaplan-Meier survival...Continue Reading

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Citations

Dec 4, 2003·Mutation Research·Riccardo PuntoniStefano Bonassi
May 24, 2008·Journal of Translational Medicine·Alessandra VerdinaAlfonso Baldi
Mar 7, 2006·Ultrastructural Pathology·John Hicks
Sep 12, 2015·Critical Reviews in Oncology/hematology·Loredana UrsoGiulia Pasello
Nov 24, 2004·Thoracic Surgery Clinics·John J Godleski
Sep 12, 2006·The International Journal of Biochemistry & Cell Biology·Enrico P SpugniniAlfonso Baldi
Oct 12, 2005·Cancer Letters·Bryan A Whitson, Robert A Kratzke
Aug 22, 2003·Clinical Journal of Oncology Nursing·Carol Brueggen, Mary Ellen Cordes
Feb 28, 2019·Cranio : the Journal of Craniomandibular Practice·Wojciech KondratJohn Radke
Nov 1, 2012·Thoracic Cancer·Vincenzo AmbrogiUNKNOWN Multidisciplinary Tor Vergata University Study Group for Malignant Pleural Mesothelioma
May 30, 2003·Experimental Biology and Medicine·Daya Upadhyay, David W Kamp
Oct 26, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Enrico P SpugniniAlfonso Baldi
Feb 4, 2010·Molecular Cancer·Daniela StoppoloniRossella Galati

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