Abstract
Small-cell neuroendocrine carcinoma of the uterine cervix (SCCC), a rare but malignant cervical neoplasm, has a highly aggressive phenotype that requires more intensive treatment than other cervical tumors. Immunohistochemical methods were used to compare the expression of p21Cip1/Waf1 and p27Kip1 in SCCC and squamous cell carcinoma, the most common type of cervical cancer. In SCCC, p21 expression was significantly reduced compared with squamous cell carcinoma, whereas expression of p27 was similar in both carcinomas. Reduced expression of p21 could be a helpful diagnostic marker and may contribute to the invasive phenotype of SCCC.
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Citations
Jun 15, 2012·Archives of Gynecology and Obstetrics·Peng PengShen Keng
Jan 23, 2013·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Dandan JiangFunian Li
Feb 3, 2012·Histopathology·Seung Yeon HaBoram Seo