PMID: 9541210Apr 16, 1998Paper

Expression of p21(WAF1/CIP1) during mouse odontogenesis

European Journal of Oral Sciences
A Bloch-ZupanJ V Ruch

Abstract

p21(WAF1/CIP1) is a cyclin-dependent kinase (Cdk) inhibitor. This protein may function during development as an inducible growth inhibitor that contributes to cell cycle exit and differentiation. The expression pattern of p21 during mouse embryogenesis was correlated with terminal differentiation of multiple cell lineages including skeletal muscles, cartilage, skin and nasal epithelium. p21 expression was analyzed by in situ hybridization during odontogenesis as well as during in vitro tooth development in chemically defined medium with or without retinoic acid. p21 transcripts were detected in the restricted area of the inner dental epithelium during late cap and initial bell stages and then confined to the post-mitotic odontoblasts and ameloblasts. The replicating cells were devoid of any signal. The distribution of p21 mRNA in vitro, whatever the culture conditions, was similar to the in vivo pattern. p21 protein immunolocalization was superimposed on the transcripts distribution but more restricted in ameloblasts. TGFbeta1 is known to induce p21 expression. During dental cytodifferentiations, TGFbeta1 and p21 expressions overlap. Growth inhibition by TGFbeta1 may be associated with p21 induction.

Citations

Mar 23, 2004·Annals of the New York Academy of Sciences·Renata PeterkováHervé Lesot
Feb 6, 2014·Australian Dental Journal·H LesotR Peterkova
Jun 5, 2015·Archives of Oral Biology·Chihiro NakatomiHayato Ohshima
Mar 8, 2000·Mechanisms of Development·J Jernvall, I Thesleff
Nov 21, 2007·Developmental Biology·Fei LiuSarah E Millar
Jul 5, 2002·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·R ToddD T Wong
May 11, 2002·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·A J Smith, H Lesot
Jun 26, 2007·Journal of Dental Research·C SahlbergS Alaluusua
Mar 19, 2003·Advances in Dental Research·H LesotJ V Ruch
Dec 8, 2004·The Journal of Cell Biology·Satoshi FukumotoYoshihiko Yamada
Apr 4, 2020·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Masanori TakahashiKiyoshi Kawakami

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