PMID: 9635534Jul 11, 1998Paper

Expression of p21WAF1/CIP1 in adenocarcinoma of the uterine cervix: a possible immunohistochemical marker of a favorable prognosis

Cancer
X LuS Fujii

Abstract

The purpose of this study was to assess the prognostic significance of the expression of estrogen receptor and cell cycle regulatory gene products in cervical adenocarcinoma. In 40 cases of adenocarcinoma of the uterine cervix and 10 normal cervices, expression of estrogen receptor and cell cycle regulatory gene products (cyclin E, p16, p21WAF1/CIP1, p27, p53, and Ki-67) was studied using immunohistochemical techniques. The survival of the patients was analyzed in terms of such variables as the expression of these molecules in the tumor and conventional clinicopathologic features, and the Cox proportional hazards model was used to predict the survival of patients with cervical adenocarcinoma. Expression of estrogen receptor was consistently observed in normal cervical glands, but in cervical adenocarcinoma it was lost (in 28 cases) or significantly diminished (in 12 cases). Normal cervical glandular cells were usually negative for the cell cycle regulatory gene products, whereas 47.5-85% of cervical adenocarcinomas were positive for these molecules. When the expression of these molecules was analyzed, significant positive correlations were found between p16 and p27, cyclin E and p27, and cyclin E and p21WAF1/CIP1. Univariate su...Continue Reading

References

May 1, 1992·American Journal of Obstetrics and Gynecology·H Anton-CulverA Manetta
Jan 1, 1990·Cancer·A LeminenE Vesterinen
Apr 15, 1986·Cancer·P E SaigoJ L Lewis
Nov 1, 1989·Gynecologic Oncology·W KleineA Pfleiderer
Jun 6, 1995·Proceedings of the National Academy of Sciences of the United States of America·A DuttaS Lester
Dec 16, 1994·Science·L H Hartwell, M B Kastan
Nov 19, 1993·Cell·W S el-DeiryB Vogelstein
Jan 1, 1993·Virchows Archiv. A, Pathological Anatomy and Histopathology·K M MitchellD Smith
Jun 18, 1993·Cell·C J Sherr
Nov 1, 1995·Japanese Journal of Cancer Research : Gann·H TsudaS Hirohashi
Mar 1, 1996·Nature Medicine·Q P DouK Keyomarsi
Jan 1, 1996·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·K Oka, T Arai
Dec 24, 1996·Proceedings of the National Academy of Sciences of the United States of America·J Gray-BablinK Keyomarsi
Apr 1, 1997·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·T TokiS Fujii
Apr 1, 1997·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·B A WernessM S Piver

❮ Previous
Next ❯

Citations

May 15, 2009·Nature Reviews. Cancer·Tarek Abbas, Anindya Dutta
Mar 10, 2005·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Paivi SiironenCaj Haglund
Oct 4, 2012·Critical Reviews in Oncology/hematology·Angiolo GadducciCarlo Greco
May 13, 2011·European Journal of Cell Biology·Benjamin Pierre BouchetAlain Puisieux
Jun 18, 2003·Journal of Cellular Physiology·Karin Milde-Langosch, Sabine Riethdorf
Mar 26, 2004·American Journal of Obstetrics and Gynecology·John O SchorgeRaheela Ashfaq
Jan 7, 2014·Biochimica Et Biophysica Acta·Antonio Carlos de FreitasMaria da Conceição Gomes Leitão
Nov 1, 2005·Yonsei Medical Journal·Young Tae Kim, Min Zhao
Nov 7, 2000·Cancer·A C HanH Salazar
Mar 17, 2000·International Journal of Cancer. Journal International Du Cancer·T K ZirbesH P Dienes
Apr 25, 2006·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Akihiko HashiKazuhiko Hoshi
Jan 22, 2008·International Journal of Surgical Pathology·Tatsuki R KataokaYasuko Nishizawa
Sep 23, 2003·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Mitsuya IshikawaShiro Nozawa
Sep 21, 2007·Annals of Surgical Oncology·Adrienne MelckSam M Wiseman
Jun 7, 2005·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Shi LuZehua Wang
Jul 17, 1999·British Journal of Cancer·R NakashimaY Murata
Nov 23, 2018·Journal of Cell Communication and Signaling·Afak Rasheed Salman ZaidiLynn McCallum

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

Cell Cycle Pathways

Cell cycle is a complex process regulated by several signal transduction pathways and enzymes. Here is the latest research on regulation of cell cycle and cell cycle pathways.