Abstract
During carcinogenesis, stromal fibroblasts undergo certain changes in concert with their neoplastic neighbors, an interaction that progressively leads to a cancer-associated state. However, despite the increasing appreciation of the importance of stromal/tumor interactions in the progression of cancer, little is known about the factors responsible for regulating the crosstalk between stromal fibroblasts and neoplastic cells. Here we show that the stage of the disease in primary human breast lesions affects p21 expression in the fibroblasts. In stromal fibroblasts of benign fibroadenomas, p21 exhibits a periductal pattern of staining, which is abolished in malignant adenocarcinomas in which p21 immunopositivity exhibits a mosaic pattern that eventually is abolished in more aggressive types of the disease. In order to address the role of fibroblasts' p21 in tumorigenesis, we have reconstituted MCF7 human breast cancers in mice, with fibroblasts differing in the p21 status. These experiments showed that p21 deficiency in stromal fibroblasts accelerates tumor growth through cell non-autonomous mechanism(s). In addition, even a transient, siRNA-mediated p21 suppression in fibroblasts sufficiently stimulates MCF7 and MDA-MB-231 growt...Continue Reading
References
Oct 12, 1995·Nature·J BrugarolasG J Hannon
Nov 19, 1993·Cell·W S el-DeiryB Vogelstein
Mar 18, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A D ThorS M Edgerton
Feb 13, 2001·Current Opinion in Genetics & Development·T D Tlsty, P W Hein
Mar 10, 2001·Experimental Cell Research·B Elenbaas, R A Weinberg
Oct 16, 2002·Nature Genetics·Keisuke KuroseCharis Eng
Jan 7, 2004·Cancer Cell·Robert H Weiss
Mar 31, 2004·Proceedings of the National Academy of Sciences of the United States of America·Charlotte KuperwasserRobert A Weinberg
Sep 15, 2004·Molecular and Cellular Biochemistry·H KiarisA Kalofoutis
Mar 9, 2005·Cancer Research·Hippokratis KiarisAnastasios Kalofoutis
Dec 20, 2005·Cell·Reginald HillTerry Van Dyke
Dec 21, 2007·The New England Journal of Medicine·Attila PatocsCharis Eng
May 31, 2008·International Journal of Cancer. Journal International Du Cancer·Daniel LafkasHippokratis Kiaris
Citations
Nov 2, 2012·Cancer Metastasis Reviews·Yan MaoJianhua Wang
May 12, 2011·Cellular Oncology (Dordrecht)·Ioulia ChatzistamouAthanasios G Papavassiliou
Jul 4, 2012·Oncogene·M M Al-AnsariA Aboussekhra
Mar 15, 2013·Genes & Cancer·Elena FarmakiHippokratis Kiaris
Aug 21, 2013·PloS One·Guohua RongHaichen Sun
Sep 26, 2013·International Journal of Oncology·Siang-Yo LinJohn Glod
Nov 2, 2013·Cancer Treatment Reviews·Steven L WoodAnthony D Whetton
Jul 1, 2014·Cancers·Kim De VeirmanKarin Vanderkerken
Jun 20, 2014·Carcinogenesis·Tomer CooksMoshe Oren
Aug 26, 2014·Nature Cell Biology·Masayuki ShimodaRama Khokha
Jan 23, 2016·Frontiers of Medicine·Aixiu QiaoLi Fu
Jun 12, 2009·Oral Oncology·Olga Zolochevska, Marxa L Figueiredo
Mar 19, 2016·Journal of Cancer Research and Clinical Oncology·Hailong FuWenrong Xu
Jun 17, 2009·International Journal of Cancer. Journal International Du Cancer·Patricia Bortman RozenchanMaria Mitzi Brentani
Dec 9, 2014·Nucleus·Henry D HerceM Cristina Cardoso
Nov 17, 2009·Seminars in Cell & Developmental Biology·Jair BarMoshe Oren
Jul 10, 2009·Molecular Cancer·David G MollevíAlberto Villanueva
Feb 12, 2015·Endocrine-related Cancer·Chrysovalantou MihailidouHippokratis Kiaris
Feb 12, 2015·Endocrine-related Cancer·Chrysovalantou MihailidouHippokratis Kiaris
May 18, 2016·Oncogene·E FarmakiH Kiaris
Aug 4, 2016·BMC Cancer·Maha A Al-RakanAbdelilah Aboussekhra
Sep 12, 2018·The Journal of Clinical Investigation·Yingying WangJianhua Wang
Dec 31, 2015·Oncotarget·Fang-Lan LiuShao-Hui Cai
Sep 25, 2018·Helicobacter·Gracjana Krzysiek-MaczkaAgata Ptak-Belowska
Mar 30, 2018·Frontiers in Oncology·Maria Kalli, Triantafyllos Stylianopoulos
Apr 21, 2016·Molecular Oncology·Konstantinos G SidiropoulosGeorge M Yousef
Sep 19, 2014·The Journal of Biological Chemistry·Siti-Fauziah HendrayaniAbdelilah Aboussekhra
Sep 19, 2018·Scientific Reports·Sreelatha K HemalathaPriya Srinivas
Mar 14, 2020·Pancreas·Francesco Di Maggio, Karim Hussien El-Shakankery
Feb 28, 2021·Cell Communication and Signaling : CCS·Jason D DomogauerEdouard I Azzam