Expression of p27 and its ubiquitin ligase subunit Skp2 in upper urinary tract transitional cell carcinoma

Urology
Cord LangnerRichard Zigeuner

Abstract

To analyze p27 and S-phase kinase-associated protein 2 (Skp2) expression in upper urinary tract transitional cell carcinoma (TCC) with respect to biologic significance. p27 (p27/kip1) is involved in cell cycle control, and loss of p27 protein expression may result in tumor development and/or progression. The association of p27 with the ubiquitin ligase subunit Skp2 targets p27 for degradation. A total of 53 upper urinary tract TCC specimens were investigated immunohistochemically using a tissue microarray technique. The immunoreactivity of p27 and Skp2 was analyzed with respect to associations with pT stage, grade, and prognosis. Non-neoplastic renal tissue showed p27 immunoreactivity in tubule epithelium and pelvic urothelium, but lacked immunoreactivity for Skp2. In the TCC specimens, p27 immunoreactivity was noted in 47 (89%) of 53 cases. High p27 expression (50% or greater of tumor cell nuclei) tended to decrease with rising tumor stage (14 [45%] of 31 with pT1-pT2 versus 4 [18%] of 22 with pT3; P = 0.076), but was independent of tumor grade (11 [39%] of 28 grade 2 versus 7 [28%] of 25 grade 3-4; P = 0.56). Skp2 immunoreactivity was noted in 32 (60%) of 53 tumors. Skp2 expression increased with rising tumor stage (9 [41%] o...Continue Reading

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Citations

Mar 27, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Shau-Hsuan LiHsuan-Ying Huang
Feb 21, 2007·International Urology and Nephrology·Ambrosi PertiaArchil Chkhotua
Aug 6, 2008·International Urology and Nephrology·Ambrosi PertiaArchil Chkhotua
May 15, 2007·The Journal of Urology·Kazumori KawakamiMasayuki Nakagawa
Mar 12, 2013·The American Journal of Pathology·Christopher SistrunkMarcelo L Rodriguez-Puebla
Oct 31, 2012·Molecular Aspects of Medicine·Niki ChondrogianniEfstathios S Gonos
Apr 25, 2006·Nature Reviews. Cancer·Keiichi I Nakayama, Keiko Nakayama
May 22, 2013·Journal of Cancer Research and Clinical Oncology·Anne Catharina DresslerChristian F Singer
Sep 16, 2020·Journal of the Egyptian National Cancer Institute·Nabiha MissaouiSihem Hmissa
Jan 24, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hsuan-Ying HuangChing-Yeh Hsiung

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