Expression of p270 (ARID1A), a component of human SWI/SNF complexes, in human tumors

International Journal of Cancer. Journal International Du Cancer
Xiaomei WangElizabeth Moran

Abstract

Human SWI/SNF complexes use the energy of ATP hydrolysis to remodel chromosomes and alter gene expression patterns. The activity of the complexes generally promotes tissue-specific gene expression and restricts cell proliferation. The ATPase that drives the complexes, BRG1, is essential for tumor suppression in mice and deficient in a variety of established human tumor cell lines. The complex contains at least 7 other core components, one of which is a large subunit designated p270. p270 RNA is expressed in all normal human tissues examined, but protein expression is severely reduced in at least 2 human tumor lines, C33A and T47D. We show here that loss of p270 in the C33A and T47D cell lines is evident at the RNA level as well as the protein level. The implication that p270 can be informatively screened at the RNA level made a high-efficiency cancer profiling array approach to screening human tumors feasible. Expression was screened in an array containing RNA-derived cDNA from 241 tumor and corresponding matched normal tissues from individual patients. p270 deficiency was observed at a higher overall frequency than BRG1 deficiency, but all tissues were not equally affected. Deficiency of p270 was observed most frequently in ca...Continue Reading

Citations

Jun 8, 2011·Cell and Tissue Research·Angel Flores-AlcantarHilda Lomelí
Apr 27, 2012·Current Oncology Reports·Leslie J FarberBin Tean Teh
Jun 1, 2005·Genomics·Deborah WilskerElizabeth Moran
Mar 2, 2011·Cell Research·Diana C Hargreaves, Gerald R Crabtree
Feb 4, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Eleftherios P SamartzisPatrick Imesch
Sep 28, 2013·Nature Genetics·Giovanni CirielloChris Sander
Oct 15, 2010·The New England Journal of Medicine·Michael J Birrer
Oct 15, 2010·The New England Journal of Medicine·Kimberly C WiegandDavid G Huntsman
Dec 21, 2011·The Journal of Biological Chemistry·Fuhua XuElizabeth Moran
Jan 11, 2005·Nucleic Acids Research·Antonia PatsialouElizabeth Moran
Dec 5, 2012·Cancer Discovery·Jennifer N Wu, Charles W M Roberts
Dec 12, 2012·International Journal of Oncology·Masakatsu NumataYohei Miyagi
Jan 17, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jing ZhaoZuowei Zhao
May 17, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Chengyao XieEnhua Wang
Jan 21, 2016·Clinical Genitourinary Cancer·Joseph ClemonsShaheen Alanee
Nov 29, 2015·Biochemical and Biophysical Research Communications·Nicholas W BatemanThomas P Conrads
Jun 17, 2016·Molecular & Cellular Oncology·Benjamin G BitlerRugang Zhang
Apr 20, 2012·The Journal of Pathology·David J McBrideDavid Dl Bowtell
Aug 26, 2015·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Dudu Solakoglu KahramanAykut Ozdemir
Dec 20, 2014·European Journal of Clinical Investigation·Márcia Vieira-CoimbraCarmen Jerónimo
Feb 26, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yi ZhangPing He
Dec 2, 2010·The Biochemical Journal·Hiroko InoueNaoko Tanese
Mar 13, 2014·Cancer Biology & Therapy·Ren-Chin WuIe-Ming Shih
Feb 19, 2013·The American Journal of Pathology·Zsuzsanna LichnerGeorge M Yousef
Mar 11, 2016·Biology of Reproduction·Xiyin WangShannon M Hawkins
Oct 30, 2013·Journal of Gynecologic Oncology·Tsui-Lien Mao, Ie-Ming Shih
Feb 22, 2014·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Zheng-mao ZhangBao-en Shan
May 12, 2007·Genes, Chromosomes & Cancer·Jianmin HuangSheng Xiao
Feb 24, 2009·Oncogene·D ReismanE A Thompson
Jul 3, 2019·American Journal of Clinical Pathology·Yoshihiro KishidaHiroyuki Ono
Aug 20, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Keerakarn SomsuanVisith Thongboonkerd
Apr 27, 2020·BMC Cancer·Mehran ErfaniHassan Ashktorab

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.