Expression of P2X3 and TRPV1 receptors in primary sensory neurons from estrogen receptors-α and estrogen receptor-β knockout mice.

Neuroreport
Taehoon Cho, Victor V Chaban

Abstract

In women, pain symptoms and nociceptive thresholds vary with the reproductive cycle, suggesting the role of estrogen receptors (ERs) in modulating nociception. Our previous data strongly suggest an interaction between ERs and ATP-induced purinergic (P2X3) as well as ERs and capsaicin-induced vanilloid (TRPV1) receptors at the level of dorsal root ganglion (DRG) neurons. In this study, we investigated the expression of P2X3 and TRPV1 receptors by western blotting and immunohistochemistry in lumbosacral DRGs from wild type, ERα, and ERβ knockout mice. We found a significant decrease for both P2X3 and TRPV1 in ERαKO and ERβKO. This phenomenon was visualized in L1, L2, L4, and L6 levels for P2X3 receptors and in L1, L2, and S2 levels for TRPV1 receptors. This tan interaction between P2X3/TRPV1 and ERs expression in sensory neurons may represent a novel mechanism that can explain the sex differences in nociception observed in clinical practice. The DRG is an important site of visceral afferent convergence and cross-sensitization and a potential target for designing new anti-nociceptive therapies.

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Citations

Oct 19, 2013·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Jianfeng YuDonghong Cui
Aug 23, 2016·Obstetrics and Gynecology·Wei Ting XiaMartin J Quinn
Sep 22, 2016·Neural Regeneration Research·Ricardo Ramírez-BarrantesPablo Olivero
Jul 1, 2017·Reproductive Sciences·Clara BörnerSylvia Mechsner
May 5, 2017·American Journal of Physiology. Renal Physiology·Eman Y GoharDavid M Pollock
May 31, 2020·International Journal of Molecular Sciences·Karina Angélica Méndez-ReséndizSara Luz Morales-Lázaro
Jul 17, 2014·The Journal of Clinical Endocrinology and Metabolism·Erin GreavesPhilippa T K Saunders
Sep 16, 2020·Biology of Sex Differences·Eman Y GoharDavid M Pollock
Aug 30, 2018·Frontiers in Molecular Biosciences·Maite Artero-MoralesAntonio Ferrer-Montiel
Jun 13, 2020·Frontiers in Physiology·Ricardo Ramírez-BarrantesPablo Olivero
Nov 22, 2013·American Journal of Physiology. Renal Physiology·Chen-Li Cheng, William C de Groat
Oct 6, 2020·Purinergic Signalling·Kazuhide Inoue
Feb 12, 2021·Biology of Sex Differences·Qing ChenXinzhong Chen
Nov 14, 2020·Biology of Sex Differences·Katja Linher-MelvilleGurmit Singh
Mar 31, 2021·Rheumatic Diseases Clinics of North America·Lauriane DelayMaripat Corr

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