Expression of P2X6 receptors in the enteric nervous system of the rat gastrointestinal tract.

Histochemistry and Cell Biology
Qiang YuZhenghua Xiang

Abstract

Expression of P2X(4) and P2X(6) receptor subunits in the gastrointestinal tract of the rat was studied with double-labeling fluorescence immunohistochemistry. The results showed that P2X(6) receptors were expressed widely in the submucosal and myenteric plexuses. In the myenteric plexus, P2X(6) receptors were expressed mainly in large size neurons which resembled Dogiel type II neurons. These P2X(6) receptor-immunoreactive (ir) neurons also expressed calbindin 28K, calretinin and neuronal nuclei (NeuN), proteins that are markers of intrinsic sensory neurons. In the submucosal plexus, all the calbindin 28K, calretinin and NeuN-ir cells were immunoreactive for P2X(6) receptors. P2X(6) receptors do not form homomultimers, but rather heteromultimers with either P2X(2) or P2X(4) receptors. P2X(4) receptors were not expressed in neurons, but were expressed in macrophages of the rat gastrointestinal tract. These data indicate that P2X(6) receptors are mainly expressed on intrinsic sensory neurons and that ATP, via P2X(6) receptors probably in heteromeric combination with P2X(2) receptors, may be involved in regulating the physiological functions of these neurons.

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Citations

May 2, 2012·Purinergic Signalling·Karina Kaczmarek-HájekAnnette Nicke
Apr 10, 2013·European Journal of Pharmacology·María G Nieto-PescadorCarlos Barajas-López
Sep 25, 2012·World Journal of Gastroenterology : WJG·Márcia Sanae MizunoPatricia Castelucci
Aug 3, 2010·World Journal of Gastroenterology : WJG·Rúbia MisawaPatricia Castelucci
Aug 31, 2013·Digestive Diseases and Sciences·Kelly PalombitPatricia Castelucci
Feb 1, 2011·Histochemistry and Cell Biology·Stefan Hübner, Athina Efthymiadis
May 7, 2013·Cell and Tissue Research·Priscila Azevedo GirottiPatricia Castelucci
Jan 11, 2012·Neuroscience Letters·Guadalupe García-AlcocerLaura C Berumen
Apr 29, 2015·Digestive Diseases and Sciences·Cristina Eusébio MendesPatricia Castelucci
Jun 8, 2015·Autonomic Neuroscience : Basic & Clinical·Brian F King
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Sep 10, 2014·Histochemistry and Cell Biology·Marcos Vinícius da SilvaPatricia Castelucci
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Mar 17, 2011·Digestive Diseases and Sciences·Ariane Silva PaulinoPatricia Castelucci
Apr 24, 2016·Purinergic Signalling·Wei GuoZhenghua Xiang
Oct 17, 2014·World Journal of Gastroenterology : WJG·Márcia Sanae MizunoPatricia Castelucci
Aug 16, 2018·Cellular and Molecular Neurobiology·Liliana H Méndez-BarredoCarlos Barajas-López
Feb 9, 2019·Digestive Diseases and Sciences·Kelly PalombitPatricia Castelucci

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