Abstract
To determine the use of p40 and laminin 332 (LN332) immunostains for diagnosing metaplastic carcinoma by studying the expression of these and other routine markers in spindle cell metaplastic carcinomas and other malignant spindle cell tumours. We identified cases of spindle cell metaplastic carcinoma (n=36) and other atypical/malignant spindle cell tumours, including 20 phyllodes tumours (14 borderline, six malignant) and 23 spindle cell sarcomas (three primary to breast). Immunohistochemical staining was performed for p40 and two LN332 chains, β3 (kalinin B1) and γ2 (lamC2). The expression of these markers was compared with p63 and cytokeratins. p40 and p63 expression was seen in 21 of 36 (58.3%) and 33 of 36 (91.7%) metaplastic carcinomas, respectively. No phyllodes tumours showed stromal expression of p40 or p63. One of 23 (4.3%) sarcomas showed focal weak p63 staining. LamC2 and kalinin B1 expression was seen in 28 of 36 (77.8%) and 26 of 36 (72.2%) metaplastic carcinomas, respectively. LamC2 and kalinin B1 each showed positive stromal cell expression in two of 20 (10%) phyllodes tumours. No sarcomas showed staining with lamC2. Kalinin B1 staining was seen in 17 of 23 (73.9%) sarcomas, including two of three primary breast...Continue Reading
References
May 18, 1999·Cancer·H GobbiD L Page
Dec 21, 2002·Histopathology·J S Reis-Filho, F C Schmitt
Mar 1, 2003·Applied Immunohistochemistry & Molecular Morphology : AIMM·Jorge S Reis-FilhoFernando C Schmitt
Aug 29, 2003·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·H N KhanJ F R Robertson
Nov 11, 2003·Human Pathology·Barbara DunneIan O Ellis
Oct 19, 2004·The American Journal of Surgical Pathology·Meryem M Koker, Celina G Kleer
Feb 24, 2005·The American Journal of Surgical Pathology·Sebastian LeiblFarid Moinfar
May 28, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Leslie K DiazMichael Z Gilcrease
Feb 14, 2006·Annals of Oncology : Official Journal of the European Society for Medical Oncology·B T HennessyV Valero
Feb 18, 2006·Pathology·Gary M TseAnthony W I Lo
Mar 16, 2006·The American Journal of Surgical Pathology·Mark R CarterChristopher D M Fletcher
Jul 18, 2006·Histopathology·J S Reis-FilhoF C Schmitt
Feb 28, 2008·The American Journal of Surgical Pathology·Philip M CarpenterSharon P Wilczynski
Apr 9, 2009·Molecular Cancer Research : MCR·Philip M CarpenterSharon P Wilczynski
Nov 8, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Justin A BishopNatasha Rekhtman
Jan 20, 2012·Journal of Clinical Pathology·Yifoong ChiaPuay Hoon Tan
Mar 20, 2012·Applied Immunohistochemistry & Molecular Morphology : AIMM·Soon-Young Kwon Philip M
Feb 13, 2013·Advances in Anatomic Pathology·Sonal Varma, Sandra J Shin
Jul 23, 2013·Critical Reviews in Oncology/hematology·Gianluca SpitaleriTommaso De Pas
Jul 22, 2014·The American Journal of Surgical Pathology·Ashley Cimino-MathewsPedram Argani
Citations
Jan 16, 2016·Histopathology·Benjamin Y TanPuay Hoon Tan
Jun 20, 2016·Pathology·Alison L CheahJ Jordi Rowe
May 27, 2017·Applied Immunohistochemistry & Molecular Morphology : AIMM·Laila KhazaiMarilin Rosa
Mar 25, 2020·Advances in Anatomic Pathology·Andrew M Bellizzi
Dec 20, 2019·Journal of Medical Case Reports·Matthew W McGeeSneha D Phadke
Oct 29, 2020·Histopathology·Emad A RakhaRaluca Mihai
Oct 23, 2019·Seminars in Cancer Biology·Patricia Rousselle, Jean Yves Scoazec
Aug 29, 2020·Applied Immunohistochemistry & Molecular Morphology : AIMM·Min HanDavid J Dabbs
Jul 30, 2021·Journal of Clinical Pathology·Emad RakhaCecily Quinn