Expression of p53, Ki-67 and c-erb B2 in growth hormone-and/or prolactin-secreting pituitary adenomas

Arquivos de neuro-psiquiatria
Carlos Henrique Aguiar BotelhoLuiz Augusto Casulari

Abstract

The subcellular events implicated on the formation and behavior of pituitary adenomas are not fully understood. In this study we investigated the presence of p53, Ki-67 and c-erb B2 in 38 pituitary adenomas with immunohistochemical positivity for GH and prolactin (n=26; 68.4%), for prolactin (n=9; 23.7%) and for GH (n=3. 7.8%). The analyses revealed the following results: 24 (63.2%) tumors expressed variable positivity for c-erb B2, 11 (28.9%) expressed p53 positivity and 11 (28.9%) tumors were variably positive for Ki-67. Our results demonstrated a high percentage of GH/prolactin-, prolactin- and GH-secreting tumors with immunohistochemical positivity for c-erb B2. Once this membrane receptor is related to growth factors EGF and TGFalpha and both have a definite effect on tumor growth, our data suggest a possible role for c-erb B2 on the evolution of these tumors.

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Citations

Aug 5, 2008·Cancer Research·George VlotidesShlomo Melmed
Apr 30, 2009·Cancer Research·George VlotidesShlomo Melmed
Sep 16, 2011·Endocrine-related Cancer·Odelia CooperShlomo Melmed
Mar 17, 2012·Pathology, Research and Practice·Parvin Mahzouni, Mohammad Movahedipour
May 21, 2010·Neurological Research·Paulo Henrique Pires de AguiarLaurence Katznelson
Feb 4, 2016·Acta Cirúrgica Brasileira·Edinaldo Gonçalves de MirandaJaques Waisberg
Feb 23, 2011·Arquivos brasileiros de endocrinologia e metabologia·Luciana Ansaneli NavesAlbert Beckers
Nov 7, 2017·International Journal of Molecular Sciences·María José García-BarradoJosé Carretero
Aug 19, 2009·Neurosurgery·Fateme SalehiMichael Cusimano
Mar 22, 2012·Endocrine·Katja Kiseljak-VassiliadesMargaret E Wierman
Nov 10, 2009·Expert Review of Molecular Diagnostics·Cristiana Pistol TanaseRadu Albulescu
Jun 8, 2018·Endocrine-related Cancer·Juan Pablo PetitiAlicia Inés Torres
Aug 3, 2019·International Journal of Endocrinology and Metabolism·Shahrzad MohseniMohammadreza Mohajeri-Tehrani

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