Expression of p53, Ki-67 and cytokeratin-4 (CK4) in oral papillomas

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
M A CopeteS Y Chen

Abstract

P53 is overexpressed in more than 50% of all human cancers. A previous study suggested that p53 was also overexpressed in oral papillomas. This study was carried out to investigate whether p53 expression was correlated with expression of the cellular proliferation marker Ki-67 and the epithelial differentiation marker cytokeratin-4 (CK4) in oral papillomas. Formalin-fixed paraffin-embedded sections of 30 oral papilloma specimens and 30 unmatched normal oral mucosal specimens were processed for immunohistochemistry, using an avidin-biotin-peroxidase procedure and monoclonal antibodies. A semiquantification analysis on p53 and Ki-67 labeling indices was performed. Twenty-eight of 30 (93%) papilloma specimens were positive for p53. The percentage of p53-positive cells in the basal layer was 60.4 +/- 14.8 (mean +/- SD, n = 28), and that of Ki-67-positive cells was 26.7 +/- 14.4. There was no correlation between expression of p53 and that of Ki-67. Expression of CK4 was inversely correlated with the expression of Ki-67 but not correlated with the expression of p53.

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Citations

Sep 25, 2009·Journal of Oral Science·Thalassa E CarneiroJoão L Miranda
Aug 22, 2008·Journal of Cutaneous Pathology·Mulazim H BukhariMumtaz Hasan
Oct 30, 1998·The Annals of Otology, Rhinology, and Laryngology·Y SternR T Cotton
Aug 17, 2006·Journal of Agricultural and Food Chemistry·Wun-Yuan LinTzu-Ming Pan

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