Expression of p53 protein and tumor angiogenesis as prognostic factors in nasopharyngeal carcinoma patients

Pathology, Research and Practice
L RubioF J Vera-Sempere

Abstract

The objective of this study was to evaluate the possible prognostic significance of p53 protein overexpression and tumor angiogenesis (TA) in nasopharyngeal carcinoma (NPC) patients, together with other clinicopathological variables. Forty-two NPC patients were evaluated in relation to survival. Nuclear p53 overexpression in neoplastic and endothelial cells was detected by immunohistochemistry (IHC) with the monoclonal antibody DO-7 and the polyclonal antibody against factor VIII-related antigen, respectively. Thereafter, we evaluated p53 cases in order to determine their nuclear immunoreactivity from negative (-) to positive (+, ++, +++). In addition, microvessels were counted in the most active areas of tumor neovascularization or hotspots using an image computer analyzer (MicroImage). A Cox multiple regression survival analysis was used to determine the best prognostic indicators in NPC patients. As a result, tumor microvessel count, considered as a continuous variable, was the most important independent prognostic indicator in relation to survival (p = 0.0273), with a relative risk of death of 2,4399 [95% confidence interval = 1.1051 ; 5.3871] associated with the highest microvessel counts. Moreover, the only clinicopatholo...Continue Reading

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Oct 18, 2000·Pathology Oncology Research : POR·L RubioF J Vera-Sempere

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Citations

Feb 15, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E P HuiA T C Chan
Jun 25, 2004·Clinical Oncology : a Journal of the Royal College of Radiologists·B WeynW Jacob
Apr 30, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·Tieshan JiangMarco Mascini
Jun 30, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Wan-Teck LimEng-Huat Tan

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