Expression of p53 protein related to smoking and alcoholic beverage drinking habits in patients with esophageal cancers

Cancer Letters
H KatoH Kuwano

Abstract

In esophageal squamous cell carcinoma (SCC), we used immunohistochemical analysis to further elucidate the correlation of p53 protein expression with clinicopathological factors, as well as with risk factors, such as tobacco smoking, alcohol consumption and a family history of cancer, using odds ratios (ORs). The expression of p53 protein was demonstrated in 55.1% of 89 esophageal SCC cases examined by immunohistochemistry. The expression of p53 protein did not correlate with gender, age, histological grading, lymph node metastasis, or TNM stage. The prevalence of p53 expression was significantly higher in patients with multiple primary esophageal cancers (P<0.05). p53 expression did not correlate with prognosis in univariate survival analysis. The esophageal SCC in either smokers or alcohol users was 4.67-5.83 times more likely to express p53 protein, while the likelihood of p53 expression in patients who use both tobacco and alcohol was more than 14.0 times. However, a significant association was not found between p53 expression and a family history of cancer, this having an OR as low as 1.85. The expression of p53 protein did not correlate with clinicopathological factors and prognosis in univariate and multivariate survival...Continue Reading

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Citations

Nov 8, 2003·BMC Cancer·Mary Beth TerryHanina Hibshoosh
Jul 5, 2003·Cancer Science·Norihiro MasudaHiroyuki Kuwano
Dec 2, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A FariedH Kuwano
Mar 5, 2015·Clinical Oncology : a Journal of the Royal College of Radiologists·X C WuJ R Zhang
Nov 4, 2017·Epigenetics : Official Journal of the DNA Methylation Society·Keisuke KurimotoYasuhiro Kodera
Dec 14, 2004·World Journal of Surgery·Shoji NatsugoeTakashi Aikou
Mar 30, 2006·International Journal of Cancer. Journal International Du Cancer·Mohammad Reza AkbariSteven A Narod
Mar 31, 2004·World Journal of Gastroenterology : WJG·An-Hui WangDe-Zhong Xu

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