Expression of p63 and p16 in primary and recurrent pterygia

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Fernando S RamalhoErasmo Romão

Abstract

p63 and p16 have been described as stem-cell markers of squamous epithelium. In an attempt to obtain new insights into the pathogenesis of pterygium, this study aims to evaluate the relationship between p63 and p16 expression in primary and recurrent pterygia. Samples of primary (n=56) and recurrent (n=14) pterygia and normal bulbar conjunctival tissue (n=11) were submitted to immunohistochemical study to evaluate the expression of p63 and p16 in these tissues. Most of the cells stained for p63 were located in the basal layer of the normal conjunctiva, in the lower two-thirds of the epithelium of primary pterygia, and throughout all epithelial layers of recurrent pterygia. In normal conjunctivae, p16 expression was rarely expressed. Primary and recurrent pterygium groups exhibited increased p16 expression, with cytoplasmic staining in the primary group, and cytoplasmic or nuclear staining in the recurrent group. The overexpression of p63 and p16 observed in the present study reinforces likelihood of involvement of these genes in the pathogenesis of pterygium, perhaps related to the intense cellular turnover with substitution of superficial epithelial cells by less differentiated forms. This loss of normal cellular differentiati...Continue Reading

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Citations

Oct 13, 2010·Histochemistry and Cell Biology·Haiqing BaiGary Hin-Fai Yam
Feb 12, 2008·The Ocular Surface·Jeanie ChuiMinas T Coroneo
Jun 6, 2009·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Chunyan XueXiaojun Zhou
Feb 11, 2016·The Open Ophthalmology Journal·Halil Hüseyin CagatayMetin Ekinci
Jul 16, 2019·Survey of Ophthalmology·Ritu NagpalNamrata Sharma
Aug 10, 2021·Investigative Ophthalmology & Visual Science·Chun-Chieh LaiChi-Chang Shieh

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