Expression of parasite genetic variation changes over the course of infection: implications of within-host dynamics for the evolution of virulence

Proceedings. Biological Sciences
Melanie ClercMatthew D Hall

Abstract

How infectious disease agents interact with their host changes during the course of infection and can alter the expression of disease-related traits. Yet by measuring parasite life-history traits at one or few moments during infection, studies have overlooked the impact of variable parasite growth trajectories on disease evolution. Here we show that infection-age-specific estimates of host and parasite fitness components can reveal new insight into the evolution of parasites. We do so by characterizing the within-host dynamics over an entire infection period for five genotypes of the castrating bacterial parasite Pasteuria ramosa infecting the crustacean Daphnia magna. Our results reveal that genetic variation for parasite-induced gigantism, host castration and parasite spore loads increases with the age of infection. Driving these patterns appears to be variation in how well the parasite maintains control of host reproduction late in the infection process. We discuss the evolutionary consequences of this finding with regard to natural selection acting on different ages of infection and the mechanism underlying the maintenance of castration efficiency. Our results highlight how elucidating within-host dynamics can shed light on...Continue Reading

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Citations

Apr 15, 2016·Evolution; International Journal of Organic Evolution·Stephen A Y Gipson, Matthew D Hall
Dec 4, 2015·PLoS Pathogens·Jessica L AbbateSébastien Lion
Jun 20, 2019·Biology Letters·Louise Solveig NørgaardMatthew D Hall
Jul 10, 2019·Molecular Ecology·Matthew D HallDieter Ebert
May 31, 2019·Global Change Biology·Tobias E HectorMatthew D Hall
Feb 23, 2020·Proceedings. Biological Sciences·Frida Ben-AmiRoland R Regoes
Jul 21, 2020·The Journal of Animal Ecology·Giacomo Zilio, Jacob C Koella
Aug 29, 2018·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Matthew D Hall, Nicole Mideo
Dec 31, 2017·Journal of Evolutionary Biology·S A Y Gipson, M D Hall
Nov 27, 2016·BMC Evolutionary Biology·Jessica MichelMatthew D Hall
Apr 21, 2017·Scientific Reports·Olivia ThompsonMatthew D Hall
May 22, 2019·Evolution; International Journal of Organic Evolution·Stephen A Y GipsonMatthew D Hall
Dec 12, 2020·Ecology and Evolution·Tess LaidlawMatthew D Hall
Jun 16, 2021·Biology Letters·Tobias E HectorMatthew D Hall
Jun 26, 2021·Global Change Biology·Tobias E HectorMatthew D Hall

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