Expression of parathyroid hormone (PTH)-related peptide (PTHrP) and PTH/PTHrP receptor in giant cell tumour of tendon sheath

The Journal of Pathology
M NakashimaI Sekine

Abstract

The giant cell tumour of tendon sheath (GCTTS) is mainly composed of mononucleated stromal cells (SC) and multinucleated giant cells (GC), so-called osteoclast-like GC. It is thought that GC are derived from SC, but their precise relationship is not fully understood. Parathyroid hormone (PTH)-related peptide (PTHrP) is now considered to be a cytokine for cell differentiation, which may stimulate osteoclast-like cell formation in haematopoietic cells. Five cases of GCTTS were evaluated immunohistochemically, using a variety of antibodies against PTHrP, PTH/PTHrP receptor, KP-1 as a histiocytic phenotypic antigen, fibronectin as a fibroblastic phenotypic antigen, and proliferating cell nuclear antigen (PCNA). In situ hybridization and immunohistochemistry revealed that in all cases both SC and GC expressed PTHrP. PTH/PTHrP receptor was observed only in histiocytic SC and GC, but not in fibroblastic SC. Almost all GC showed histiocytic features. PCNA immunoreactivity was detected only in the nuclei of SC, and not in GC. Moreover, SC with PTH/PTHrP receptor immunoreactivity were negative for PCNA. These results suggest that GC are derived from histiocytic SC expressing PTH/PTHrP receptor and losing proliferative activity in the pro...Continue Reading

References

Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J M MoseleyJ D Zajac
Jul 1, 1985·Pathology, Research and Practice·V BouropoulouZ Manika
Apr 1, 1968·The Journal of Bone and Joint Surgery. American Volume·R Eisenstein
Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger
Mar 1, 1980·Acta Pathologica Japonica·H HashimotoM Enjoji
Feb 1, 1995·The Journal of Pathology·M NakashimaS Yamashita
Dec 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·E C WeirK L Insogna

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Citations

Aug 22, 2003·Thyroid : Official Journal of the American Thyroid Association·Serik MeirmanovIchiro Sekine
Mar 30, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M C LangubH H Malluche
Feb 9, 2010·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Yuko YoshihiroShinji Naito
Aug 4, 2006·European Journal of Clinical Investigation·H H MallucheH Mawad
Nov 22, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Robert W CowanMichelle Ghert
May 16, 2003·Pathology, Research and Practice·Masahiro NakashimaIchiro Sekine
Jun 1, 1997·The Journal of Pathology·G K AlipovI Sekine

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