Expression of parathyroid hormone-related peptide in human osteoarthritis

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
K OkanoS Yamashita

Abstract

To evaluate the involvement of the expression of parathyroid hormone-related peptide gene in human articular cartilage pathology, we performed immunohistochemical staining and in situ hybridization on specimens of femoral head cartilage obtained from 15 patients with osteoarthritis, 11 with rheumatoid arthritis, and 12 control subjects. Parathyroid hormone-related peptide-positive chondrocytes were observed predominantly in degenerated lesions of osteoarthritic tissue and were less evident in rheumatoid arthritic samples, while the normal cartilage expressed little parathyroid hormone-related peptide. In addition, the level of parathyroid hormone-related peptide expression was clearly dependent on the degree of cartilage degeneration; cartilage tissues with moderate degenerative changes contained more positive chondrocytes compared with mildly or severely degenerated cartilage. In situ hybridization confirmed the localization of parathyroid hormone-related peptide protein and demonstrated intense expression of mRNA of the peptide in osteoarthritic samples. This is the first demonstration of parathyroid hormone-related peptide expression in chondrocytes from pathologic articular cartilage of humans. Our results suggest that para...Continue Reading

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Citations

Dec 11, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Stacy A SemevolosAlan J Nixon
Sep 8, 2012·Annals of the Rheumatic Diseases·Katherine S ElliottUNKNOWN arcOGEN consortium
Jul 23, 2013·Journal of Medical Genetics·Kalliope Panoutsopoulou, Eleftheria Zeggini
Oct 9, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Alicia H WhiteGillian A Wallis
Oct 15, 2003·Arthritis and Rheumatism·Maryse PicherGreta M Lee
Sep 20, 2005·Osteoarthritis and Cartilage·C SanchezY E Henrotin
Nov 20, 2012·Osteoarthritis and Cartilage·R E MitchellC L Hammond
Apr 28, 2010·Journal of Orthopaedic Surgery and Research·Christoph BecherCarsten O Tibesku
Jun 22, 2006·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Stacy A SemevolosJennifer Haupt
Apr 15, 2003·Histochemistry and Cell Biology·Klaus HuchRolf Erwin Brenner
Apr 6, 2019·BioMed Research International·Zhi-Xi DuanZhi-Hong Li

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