PMID: 9169092Apr 1, 1997Paper

Expression of PAX3 in Ewing's sarcoma family of tumors

Biochemical and Molecular Medicine
T W SchulteL M Neckers

Abstract

The Ewing's sarcoma family of tumors (ESFT) is the second most common pediatric malignancy originating in the bone and is characterized by the t(11; 22) translocation. PAX3, a member of the paired box family of genes, is expressed during embryonal development of neural crest cells and is involved in the t(2; 13) translocation found in alveolar rhabdomyosarcoma. Since ESFTs are believed to be derived from neural crest tissue, we screened a series of Ewing's sarcoma and peripheral neuroectodermal tumor cell lines and tumor specimens for expression of PAX3. We found expression of PAX3 in most, but not all, of the specimens analyzed, including cell lines and patient material.

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Citations

Apr 1, 2009·Apoptosis : an International Journal on Programmed Cell Death·James H ChappellMary R Loeken
Jan 11, 2012·Journal of Molecular Neuroscience : MN·Jian ChenWei Shi
Jul 23, 2005·Neoplasia : an International Journal for Oncology Research·Timothy R GershonWilliam L Gerald
Jan 7, 2006·Nature Reviews. Cancer·Ewan J D RobsonMichael R Eccles
Aug 27, 2014·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Ana Almazán-MogaSoledad Gallego
May 24, 2001·The Journal of Urology·B KhoubehiC W Ogden
Apr 1, 2005·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Mary R Loeken
Dec 16, 1998·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·P S Thorner, J A Squire
Mar 4, 2019·Journal of Molecular Neuroscience : MN·Xia LiangSun Caixing

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