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Expression of PD-1 by T Cells in Malignant Glioma Patients Reflects Exhaustion and Activation

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research

Mar 15, 2019

Tom B DavidsonRobert M Prins

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Abstract

Glioblastoma (GBM) is the most common primary malignant tumor in the central nervous system. Our recent preclinical work has suggested that PD-1/PD-L1 plays an important immunoregulatory role to limit effective antitumor T-cell responses induced by active immunotherapy. However, little ...read more

Mentioned in this Paper

Antigens
Biological Markers
Malignant Neoplasms
Glioblastoma
Glioma
Immunotherapy
Memory
Neoplasms
T-Cell Receptor
T-Lymphocyte
9
17
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Expression of PD-1 by T Cells in Malignant Glioma Patients Reflects Exhaustion and Activation

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research

Mar 15, 2019

Tom B DavidsonRobert M Prins

PMID: 30498094

DOI: 10.1158/1078-0432.ccr-18-1176

Abstract

Glioblastoma (GBM) is the most common primary malignant tumor in the central nervous system. Our recent preclinical work has suggested that PD-1/PD-L1 plays an important immunoregulatory role to limit effective antitumor T-cell responses induced by active immunotherapy. However, little ...read more

Mentioned in this Paper

Antigens
Biological Markers
Malignant Neoplasms
Glioblastoma
Glioma
9
17

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