Dec 1, 2018

Expression of PD-1 by T Cells in Malignant Glioma Patients Reflects Exhaustion and Activation

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Tom B DavidsonRobert M Prins

Abstract

Glioblastoma (GBM) is the most common primary malignant tumor in the central nervous system. Our recent preclinical work has suggested that PD-1/PD-L1 plays an important immunoregulatory role to limit effective antitumor T-cell responses induced by active immunotherapy. However, little is known about the functional role that PD-1 plays on human T lymphocytes in patients with malignant glioma.Experimental Design: In this study, we examined the immune landscape and function of PD-1 expression by T cells from tumor and peripheral blood in patients with malignant glioma. We found several differences between PD-1+ tumor-infiltrating lymphocytes (TIL) and patient-matched PD-1+ peripheral blood T lymphocytes. Phenotypically, PD-1+ TILs exhibited higher expression of markers of activation and exhaustion than peripheral blood PD-1+ T cells, which instead had increased markers of memory. A comparison of the T-cell receptor variable chain populations revealed decreased diversity in T cells that expressed PD-1, regardless of the location obtained. Functionally, peripheral blood PD-1+ T cells had a significantly increased proliferative capacity upon activation compared with PD-1- T cells. Our evidence suggests that PD-1 expression in patien...Continue Reading

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Mentioned in this Paper

Biological Markers
Study
Immune Response
T-Lymphocyte
Peripheral Blood
SNCA
Neoplasms
Entire Central Nervous System
Malignant Mixed Tumor
Programmed Cell Death Protein 1

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