Expression of PD-L1 in keratoacanthoma and different stages of progression in cutaneous squamous cell carcinoma

Cancer Immunology, Immunotherapy : CII
Thilo GambichlerLutz Schmitz

Abstract

Programmed cell death 1 (PD-1) and its ligands (PD-L1) play a major role in the immune responses of a variety of cancers. To investigate the expression of PD-L1 in different progression forms of cutaneous squamous cell carcinoma (cSCC) and keratoacanthoma (KA). We performed immunohistochemical staining of 21 KA, 26 actinic keratoses (AK), 20 Bowen´s diseases (BD), and 26 high-risk cSCC. The staining patterns were assessed using the tumour proportion score and staining intensity evaluation. Immunohistology scores were statistically analysed. PD-L1 expression of tumour cells as well as tumour-infiltrating cells (TILs) was significantly higher in KA and cSCC when compared to AK and BD (P = 0.00028 and P = 0.00033, respectively). We observed a very strong positive correlation between the PD-L1 protein expression of tumour cells of KA and the PD-L1 protein expression of TILs (r = 0.97; P < 0.0001). A similar correlation was also found for cSCC (r = 0.86; P < 0.0001). The percentage of PD-L1 + tumours was 33.3% for KA and 26.9% for cSCC. Similarly, the percentage of PD-L1 + TILs in KA and cSCC was 33.3 and 34.6%, respectively. PD-L1 is differently expressed in cSCC and closely related non-melanoma skin cancer. cSCC exhibit PD-L1 expr...Continue Reading

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Citations

Aug 6, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·J P Bandino, D M Elston
May 10, 2018·The American Journal of Dermatopathology·Irene García-DíezAgustí Toll
May 30, 2019·Investigative Ophthalmology & Visual Science·Priyadharsini NagarajanBita Esmaeli
Apr 1, 2020·Journal of Immunotherapy·Thilo GambichlerKerstin Lang
May 26, 2018·Cancer Immunology, Immunotherapy : CII·Corinne BauerMoritz Felcht
Feb 10, 2019·American Journal of Clinical Dermatology·Roma Patel, Anne Lynn S Chang
Dec 16, 2019·The American Journal of Pathology·Minna PiipponenVeli-Matti Kähäri
Feb 27, 2021·Frontiers in Cell and Developmental Biology·Nádia Ghinelli AmôrAna Paula Campanelli
Apr 29, 2021·The American Journal of Dermatopathology·Larisa LehmerAshley Elsensohn
Apr 18, 2021·The British Journal of Dermatology·A TisackJ Veenstra
Jul 13, 2021·The Journal of Investigative Dermatology·Anngela C AdamsKaren Taraszka Hastings

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