Expression of PDGF alpha-receptor in renal arteriosclerosis and rejecting renal transplants.

Journal of the American Society of Nephrology : JASN
J FloegeC E Alpers

Abstract

Platelet-derived growth factor (PDGF) plays an important role in renal disease. We have recently demonstrated that in healthy mature human kidney, PDGF alpha-receptor expression is largely restricted to interstitial cells. The study presented here assesses the expression of PDGF alpha-receptor in 18 mature adult kidneys with arteriosclerosis from individuals with no clinically evident history of renal disease other than localized neoplasia, in 13 kidneys with irreversible transplant rejection, and in a series of renal transplant biopsies composed of examples of both severe and absent rejection, by in situ hybridization and immunocytochemistry. Strong focal or diffuse expression of PDGF alpha-receptor mRNA and protein was noted in some intimal cells of intrarenal arterial vessels exhibiting signs of arteriosclerosis and/or vascular rejection. By double immunostaining, it could be shown that these cells were neither endothelial cells nor infiltrating leukocytes. The cells were most often identified as smooth muscle by colabeling for the smooth muscle cell-specific protein SM22alpha and less commonly for alpha-smooth muscle actin. There was also a population of PDGF alpha-receptor-expressing cells that failed to colabel with any o...Continue Reading

Citations

Apr 23, 2003·Journal of the American Society of Nephrology : JASN·Frank EitnerUNKNOWN ERCB-Consortium
Mar 27, 2001·Transplantation Proceedings·J SavikkoE von Willebrand
Jan 29, 2002·Biochemical and Biophysical Research Communications·Kenji MatsumotoMoriaki Kusakabe
Mar 26, 2002·Journal of the American Society of Nephrology : JASN·Frank EitnerJürgen Floege
Mar 22, 2002·The New England Journal of Medicine·Richard J JohnsonBernardo Rodriguez-Iturbe
Nov 13, 2002·Kidney International·Charles E AlpersJames A Bassuk
Jun 23, 2004·Cytokine & Growth Factor Reviews·Elaine W Raines
Jun 23, 2004·Cytokine & Growth Factor Reviews·James C Bonner
Feb 18, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ilkka HelanteräIrmeli Lautenschlager
Oct 21, 2005·Journal of the American Society of Nephrology : JASN·Giovanni StalloneGiuseppe Grandaliano
Dec 14, 2007·Journal of the American Society of Nephrology : JASN·Jürgen FloegeCharles E Alpers
Jan 25, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Helene FrançoisPierre Ronco
Sep 10, 2009·Antioxidants & Redox Signaling·Alejandra San Martín, Kathy K Griendling
Nov 10, 2009·Current Opinion in Organ Transplantation·Gary S HillAlexandre Loupy
May 22, 2010·The American Journal of Pathology·Peter BoorTammo Ostendorf
Sep 15, 2010·Nature Reviews. Nephrology·Peter BoorJürgen Floege
Feb 3, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Johanna SavikkoEva von Willebrand
May 21, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Tammo OstendorfJürgen Floege

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