PMID: 11343832May 10, 2001Paper

Expression of PEPT2 peptide transporter mRNA and protein in glial cells of rat dorsal root ganglia

Neuroscience Letters
David A GronebergAxel Fischer

Abstract

The peptide-transporter PEPT2 mediates electrogenic uphill transport of di- and tripeptides, selected peptidomimetics and delta aminolevulinic acid. The transporter was cloned from rat central nervous tissue recently and its mRNA was localized to astrocytes. In the present studies the expression of PEPT2-protein and -mRNA in rat dorsal root ganglia was investigated. Immunohistochemistry revealed PEPT2-immunoreactivity in satellite glial cells surrounding the ganglionic neurons. There was no expression in neuronal cells. In-situ-hybridization studies colocalized the expression of PEPT2-mRNA to satellite cells. This is the first report on the expression of PEPT2-protein in the peripheral nervous system where PEPT2 may serve as uptake system for products of protein degradation, for removal of biologically active short-chain peptides and non-peptides such as delta aminolevulinic acid.

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Citations

Sep 19, 2002·Trends in Pharmacological Sciences·Isabel Rubio-Aliaga, Hannelore Daniel
Feb 19, 2004·American Journal of Respiratory Cell and Molecular Biology·David A GronebergHannelore Daniel
Jan 22, 2005·Respiratory Research·David A GronebergPeter Zabel
Dec 20, 2011·Journal of Occupational Medicine and Toxicology·Daniel MüllerDavid A Groneberg
Dec 23, 2011·Journal of Occupational Medicine and Toxicology·Daniel MuellerDavid A Groneberg
Jun 26, 2012·Journal of Occupational Medicine and Toxicology·Stefanie UibelDavid A Groneberg
Oct 11, 2013·Journal of Occupational Medicine and Toxicology·Hans D LauensteinDavid A Groneberg
Oct 6, 2005·Biological Chemistry·Frank DöringDavid A Groneberg
Aug 2, 2002·Journal of Cutaneous Pathology·Tanja C FischerDavid A Groneberg
Jun 15, 2004·Neuroscience Letters·David A GronebergHannelore Daniel
Apr 4, 2006·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·David A GronebergTobias Welte
Sep 3, 2008·Drug Metabolism and Pharmacokinetics·Mohamed A KamalDavid E Smith
Jun 16, 2004·Experimental Lung Research·David A GronebergJochen Springer
Jun 8, 2002·Toxicologic Pathology·David A GronebergAxel Fischer
May 15, 2003·Toxicologic Pathology·David A GronebergAxel Fischer
Jul 26, 2005·The Journal of Comparative Neurology·Anne RühlMichael Schemann
Feb 1, 2018·Oncotarget·David A GronebergDörthe Brüggmann
Apr 5, 2003·American Journal of Physiology. Renal Physiology·Hannelore Daniel, Isabel Rubio-Aliaga
Apr 6, 2002·American Journal of Physiology. Endocrinology and Metabolism·David A GronebergHannelore Daniel
Aug 19, 2005·American Journal of Physiology. Cell Physiology·Maja KlapperFrank Döring
Feb 14, 2006·European Journal of Pharmacology·David A GronebergAxel Fischer
Feb 26, 2008·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Helle Bach SøndergaardBirger Brodin
Oct 22, 2013·Journal of Occupational Medicine and Toxicology·Jochen SpringerDavid A Groneberg
Jun 29, 2005·Molecular Pharmaceutics·Eric Y ZhangKathleen M Hillgren

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