Expression of Periostin in Normal, Atopic, and Nonatopic Chronically Inflamed Canine Skin

Veterinary Pathology
T MineshigeK Shirota

Abstract

In humans, periostin plays a critical role in the enhancement and chronicity of allergic skin inflammation; however, whether it is involved in the pathogenesis of canine dermatitis remains unknown. The aim of this study was to examine the expression patterns of periostin in healthy, atopic, and nonatopic chronically inflamed canine skin. Biopsy specimens from 47 dogs with skin disease and normal skin tissue from 5 adult beagles were examined by light microscopy, immunohistochemistry, and in situ hybridization. In normal skin, periostin was localized just beneath the epidermis and around the hair follicles. In chronically inflamed skin, periostin expression was most intense in the dermis with inflammatory cell infiltrates. In contrast, low levels of periostin were detected in acutely inflamed and noninflamed skin. Conversely, all canine atopic dermatitis tissues characteristically showed the most intense expression of periostin in the superficial dermis, particularly at the epidermal-dermal junction. In situ hybridization showed that periostin mRNA was broadly expressed in the basal epidermal keratinocytes, outer root sheath cells, and dermal fibroblasts in normal dog skin. High expression of periostin mRNA was observed in fibro...Continue Reading

References

Jul 11, 1975·The Journal of Investigative Dermatology·R A Briggaman, C E Wheeler
Jun 1, 1997·Veterinary Immunology and Immunopathology·J D SinkeT Willemse
Sep 13, 2001·Veterinary Immunology and Immunopathology·T Olivry, P B Hill
Mar 27, 2002·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·S HayashiyaY Taura
Jun 7, 2003·Veterinary Dermatology·T OlivryUNKNOWN International Task Force on Canine Atopic Dermatitis
Jul 4, 2006·The Journal of Allergy and Clinical Immunology·Go TakayamaKenji Izuhara
Apr 28, 2009·Journal of Dermatological Science·Shona H WoodStuart D Carter
Jun 12, 2009·The Journal of Investigative Dermatology·Rosanna Marsella, Giampiero Girolomoni
Jun 21, 2011·Veterinary Immunology and Immunopathology·Yvette M SchlotterTon Willemse
Aug 5, 2011·The New England Journal of Medicine·Jonathan CorrenJohn G Matthews
Oct 15, 2011·Virchows Archiv : an International Journal of Pathology·Laura Morra, Holger Moch
Nov 19, 2011·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E D GordonJ V Fahy
Jun 12, 2012·The Journal of Clinical Investigation·Miho MasuokaKenji Izuhara
Aug 25, 2012·Allergology International : Official Journal of the Japanese Society of Allergology·Hiroshi ShiraishiKenji Izuhara
Jan 22, 2013·Veterinary Dermatology·Jolanta Klukowska-RötzlerJozef Janda
Dec 20, 2013·The Journal of Investigative Dermatology·Kazuto TaniguchiKenji Izuhara
Apr 25, 2014·Allergology International : Official Journal of the Japanese Society of Allergology·Yukie Yamaguchi
Jan 1, 2014·Allergology International : Official Journal of the Japanese Society of Allergology·Yukie Yamaguchi

❮ Previous
Next ❯

Citations

Feb 9, 2018·The Journal of Veterinary Medical Science·Takayuki MineshigeKinji Shirota
May 29, 2016·Cell and Tissue Research·John T WalkerDouglas W Hamilton
Oct 17, 2018·Clinical and Translational Allergy·Natalie Katharina Yvonne Gedon, Ralf Steffen Mueller
May 24, 2021·The Journal of Investigative Dermatology·Takashi HashimotoGil Yosipovitch

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies
Assay

Software Mentioned

GraphPad
GraphPad Prism

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.