PMID: 25735395Mar 5, 2015Paper

Expression of PGDH correlates with cell growth in both esophageal squamous cell carcinoma and adenocarcinoma

Asian Pacific Journal of Cancer Prevention : APJCP
Guo-Tao YangZi-Ying Luan

Abstract

Esophageal cancer represents the fourth most common gastrointestinal cancer and generally confers a poor prognosis. Prostaglandin-producing cyclo-oxygenase has been implicated in the pathogenesis of esophageal cancer growth. Here we report that prostaglandin dehydrogenase, the major enzyme responsible for prostaglandin degradation, is significantly reduced in expression in esophageal cancer in comparison to normal esophageal tissue. Reconstitution of PGDH expression in esophageal cancer cells suppresses cancer cell growth, at least in part through preventing cell proliferation and promoting cell apoptosis. The tumor suppressive role of PGDH applies equally to both squamous cell carcinoma and adenocarcinoma, which enriches our understanding of the pathogenesis of esophageal cancer and may provide an important therapeutic target.

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Citations

Sep 19, 2017·PloS One·Linda C CummingsSanford D Markowitz
May 8, 2018·The Journal of Clinical Investigation·Dingzhi Wang, Raymond N DuBois

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