Expression of phosphorylated Stat3, cyclin D1 and Bcl-xL in extramammary Paget disease

The British Journal of Dermatology
H LiuK Urabe

Abstract

Stat3 (Signal transducer and activator of transcription-3) is an oncogene that plays a critical role in regulating fundamental processes associated with malignant transformation and cell survival. It participates in oncogenesis through upregulation of genes encoding apoptosis inhibitors (Bcl-xL) and cell cycle regulators (cyclin D1). The expression of Stat3, Bcl-xL and cyclin D1 protein has not been investigated in extramammary Paget disease (EMPD). To study the expression of phosphorylated Stat3 (p-Stat3), Bcl-xL and cyclin D1 protein in EMPD and to evaluate the relationships among them. Thirty-six tissue samples from 34 patients with primary EMPD were subjected to immunohistochemical staining for p-Stat3, cyclin D1 and Bcl-xL. Thirty-five of 36 specimens were clearly positive for p-Stat3 in EMPD, while 30 of 36 and 32 of 36 were positive for cyclin D1 and Bcl-xL expression, respectively. In all of four invasive EMPD specimens, strong and frequent expression of these three molecules was evident; moreover, two invasive EMPD specimens with lymph nodal metastasis showed very strong nuclear and membranous p-Stat3 staining. Two metastatic lymph node specimens showed very strong nuclear and local membrane p-Stat3 staining. There wer...Continue Reading

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Jan 23, 2008·Archives of Dermatological Research·Si-Yuan ChenMasutaka Furue
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Jan 7, 2010·The American Journal of Dermatopathology·John PerrottoIftikhar Ahmed
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Aug 17, 2018·Current Treatment Options in Oncology·Naohito Hatta
Aug 17, 2021·Frontiers in Oncology·Hiroki HashimotoTakamichi Ito

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