Expression of PINCH protein in gliomas and its clinicopathological significance

Oncology
Ming-Wei WangXiao-Feng Sun

Abstract

Particularly interesting new cysteine-histidine-rich protein (PINCH), as a LIM domain adapter protein, functions in the integrin and growth factor signal transduction pathway, and is upregulated in tumor-associated stroma in several types of cancers. However, no study of PINCH has been carried out in gliomas, therefore we examined PINCH expression in gliomas and its clinicopathological significance. PINCH expression was immunohistochemically examined in 82 gliomas, along with 26 matched adjacent normal brain samples and 10 recurred gliomas. PINCH was strongly expressed in the primary (35%, p = 0.0001) or recurred tumors (40%, p = 0.004) and weak in normal brain tissue. PINCH expression was significantly increased in high-grade gliomas (55 vs. 24%, high- vs. low-grade gliomas, p = 0.004). There was no association of PINCH expression with gender, age, tumor number, size, histological type and tumor location (p > 0.05). PINCH expression may be involved in glioma development and differentiation.

References

Jun 30, 1994·Biochemical and Biophysical Research Communications·A Rearden
Feb 22, 2005·Neoplasia : an International Journal for Oncology Research·Jingfang GaoXiao-Feng Sun
Feb 17, 2006·World Journal of Gastroenterology : WJG·Zeng-Ren ZhaoXiao-Feng Sun

❮ Previous
Next ❯

Citations

Nov 26, 2010·Nature Reviews. Cancer·Sara CabodiPaola Defilippi
Jul 2, 2010·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Courtney L ScaifeSean J Mulvihill
Oct 15, 2010·Journal of Cellular Physiology·Jane KovalevichDianne Langford

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.