PMID: 9191084Jun 1, 1997Paper

Expression of pituitary adenylate cyclase-activating polypeptide (PACAP) in the mesencephalic trigeminal nucleus of the rat after transsection of the masseteric nerve

Brain Research. Molecular Brain Research
J O LarsenJ Fahrenkrug

Abstract

Pituitary adenylate cyclase-activating polypeptide (PACAP), a member of the VIP (vasoactive intestinal polypeptide) family of peptides, has been demonstrated in neurons of the sensory system. PACAP expression of these neurons is sensitive to nerve damages such as nerve crush or axotomy. In the present study, PACAP expression in the mesencephalic trigeminal nucleus of the rat was examined after transsection of the main trunk of the masseteric nerve. The primary sensory neurons of the nucleus are considered to have purely proprioceptive functions. By quantitative in situ hybridization using a PACAP [35S]cRNA probe, an increase in PACAP mRNA was observed on the side ipsilateral to transsection already after 3 h and the expression reached a peak 24 h after surgery after which the levels gradually decreased during the next 14 days. A low and constant expression of PACAP mRNA could be seen on the side contralateral to transsection. PACAP immunoreactivity was demonstrated on the ipsilateral side after 18 h, using a specific monoclonal PACAP antibody. Co-existence of PACAP with NPY and galanin was demonstrated 7 days after transsection. Analysis of the masseteric nerve by radioimmunoassay on transsected and normal nerve stumps revealed...Continue Reading

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Citations

Jul 16, 2008·Journal of Molecular Neuroscience : MN·Eszter VarhalmiLaszlo Molnar
Apr 25, 2012·Journal of Molecular Neuroscience : MN·D ReglodiA Tamas
Jan 23, 1999·Current Opinion in Neurobiology·J P LundG Scott
Dec 3, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Karen M BraasMargaret A Vizzard
Sep 4, 2012·International Journal of Molecular Sciences·Andrea TamasPeter Bukovics
Jul 17, 2012·Journal of Neural Transmission·G S LallD R Bonsall
Jun 3, 2006·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Ute Mathis, Frank Schaeffel
Jul 15, 2000·Archives of Physiology and Biochemistry·N LazarovC Chouchkov
Feb 3, 1999·Annals of the New York Academy of Sciences·J Fahrenkrug, J Hannibal
Dec 4, 2004·Journal of Lipid Research·Marie L S LindegaardLars B Nielsen
Sep 10, 2005·Journal of Lipid Research·Marie L S LindegaardLars B Nielsen
Oct 5, 2017·British Journal of Pharmacology·Tahlia Sundrum, Christopher S Walker
Dec 20, 2017·Frontiers in Systems Neuroscience·Beatrice M GirardMargaret A Vizzard
Jul 20, 2018·Journal of Molecular Neuroscience : MN·Thomas J HeppnerMargaret A Vizzard
Sep 28, 2018·Journal of Molecular Neuroscience : MN·Jacqueline OjalaMargaret A Vizzard
Oct 5, 2007·Brain Research Reviews·Nikolai E Lazarov

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