PMID: 15381908Sep 24, 2004Paper

Expression of placental leptin and leptin receptors in preeclampsia

International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists
Raymond H W LiY F Wong

Abstract

This study investigated the expression profile of placental leptin and leptin receptor isoforms in preeclampsia, using placental tissue from normal pregnancies that were matched in gestational age and birth weight as controls. A total of 29 cases of preeclampsia were studied by immunohistochemistry, including 16 severe and 13 mild preeclampsia cases. Reverse transcriptase-polymerase chain reaction (RT-PCR) was further performed using RNA extracted from frozen tissue (10 severe preeclampsia, 10 mild preeclampsia, and 20 normal third trimester placentas). In all tissue sections, immunostaining signal was shown in the cytoplasmic compartment of the trophoblastic cells. Both the severe and mild preeclampsia groups showed significantly higher immunostaining for leptin compared with normal controls (p < 0.05), but there was no significant difference between the severe and mild preeclampsia groups (p > 0.05). There was no significant difference in immunostaining for leptin receptor between both severe and mild preeclampsia compared with controls (p > 0.05). RT-PCR showed significantly higher levels of mRNA transcripts of leptin in severe preeclampsia (p < 0.05), but not mild preeclampsia (p > 0.05), compared with normal controls. No s...Continue Reading

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Citations

Nov 4, 2005·Biology of Reproduction·Michael C Henson, V Daniel Castracane
Sep 8, 2007·The American Journal of Pathology·Tereza Cindrova-DaviesD Stephen Charnock-Jones
Jan 1, 2013·Molecular and Cellular Endocrinology·Kirsten HoggWendy P Robinson
Jul 12, 2011·Pregnancy Hypertension·Virginia D WinnSusan J Fisher
May 29, 2009·Reproductive Sciences·Despina D Briana, Ariadne Malamitsi-Puchner
Jun 6, 2014·Reproductive Sciences·Pai-Jong Stacy TsaiGillian Bryant-Greenwood
Nov 23, 2012·Reproductive Sciences·Kristen K RumerVirginia D Winn
Jun 1, 2006·Current Opinion in Obstetrics & Gynecology·Ana CerveroCarlos Simón
Oct 31, 2006·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·János RigóAgota Vér
Jun 21, 2006·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Margaret MellerMichelle A Williams
Oct 28, 2019·Biochimica Et Biophysica Acta. Molecular Basis of Disease·V Arroyo-JousseP Casanello

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