PMID: 9421350Jan 8, 1998Paper

Expression of plasminogen activator inhibitor-2 in epithelial ovarian cancer: a favorable prognostic factor related to the actions of CSF-1

International Journal of Cancer. Journal International Du Cancer
S K ChambersM L Carcangiu

Abstract

In ovarian cancer cells, the macrophage colony-stimulating factor-1 (CSF-1) induces the release of plasminogen activator inhibitor-2 (PAI-2), and high levels of PAI-2 as well as of CSF-1 in ovarian cancer ascites are independently correlated with poor outcome. We now study the effect of CSF-1 on PAI-2 expression in vitro and the significance of cellular PAI-2 expression in vivo. Immunohistochemical detection of PAI-2 was studied in primary and metastatic tissues from 130 epithelial ovarian cancer cases. Kaplan-Meier curves of survival were compared with the results of log-rank test. The Cox regression model was used for multivariate analysis. The effect of CSF-1 on PAI-2 expression in ovarian cancer cells was also examined in vitro. Fifty-eight percent of the primary tumors and 68% of the metastases expressed PAI-2. PAI-2 expression in the metastases of invasive stages III and IV cases was strongly predictive of a prolonged disease-free and overall survival. This finding was associated with low residual disease and was also an independent factor for disease-free survival. In vitro, CSF-1 treatment of ovarian cancer cells resulted in a decrease in cellular staining for PAI-2 while increasing the release of PAI-2 into the conditi...Continue Reading

References

Sep 1, 1988·American Journal of Clinical Pathology·S BacusK S McCarty
Mar 1, 1989·The Journal of Clinical Investigation·S RamakrishnanE L Brown
Jan 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·B M MuellerW E Laug
Aug 19, 1993·International Journal of Cancer. Journal International Du Cancer·E Pujade-LauraineP Burtin
Feb 1, 1993·American Journal of Obstetrics and Gynecology·F V PriceB M Kacinski
Oct 1, 1994·Journal of the Society for Gynecologic Investigation·S K Chambers, B M Kacinski

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Citations

Mar 14, 2009·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Xiaofang YiSetsuko K Chambers
Nov 12, 1998·Journal of the National Cancer Institute·L M Wahl, H K Kleinman
Feb 24, 2001·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·H Yaziji, A M Gown
Jun 13, 2008·Nature Reviews. Cancer·David R CroucherMarie Ranson
Oct 7, 1998·International Journal of Cancer. Journal International Du Cancer·S K ChambersM L Carcangiu
Jun 4, 2016·Oncotarget·Tiziana de CristofaroMariastella Zannini

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