Expression of podoplanin in the invasion front of oral squamous cell carcinoma is not prognostic for survival

Virchows Archiv : an International Journal of Pathology
Juan C de VicenteVerónica Blanco-Lorenzo

Abstract

Podoplanin is involved in actin remodeling of the cytoskeleton of tumor cells and may promote tumor cell invasion by increasing cell motility and formation of filopodia-like membrane protrusions. Podoplanin is expressed in a variety of tumors, but its role in head and neck cancer, particularly in oral squamous cell carcinoma, remains unclear. We studied podoplanin expression by immunohistochemistry in 92 oral squamous cell carcinomas (OSCC) using a monoclonal antibody against an epitope of podoplanin (D2-40). In terms of the number of stained cells, 34 OSCC (38 %) had low podoplanin expression (less than 33 % of cells), 33 (36 %) showed moderate expression (between 34 and 66 % of cells), and 21 (22 %) showed high expression. The intensity of immunostaining was strong in 26 (28 %) cases, moderate in 36 (40 %), and weak or negative in the remaining 30 tumors (32 %). Immunohistochemical expression of podoplanin was associated with a tumor histological grade. A diffuse pattern of podoplanin expression significantly decreased in moderately differentiated (37 %) and poorly differentiated (20 %) carcinomas compared to well-differentiated (43 %) carcinomas. In addition, the focal expression of podoplanin in the invasion front of the tu...Continue Reading

References

Jul 1, 1987·Archives of Otolaryngology--head & Neck Surgery·P Zbären, W Lehmann
Oct 12, 2001·Microscopy Research and Technique·J P SleemanP Baumann
Jul 27, 2004·Annals of Surgery·Sebastian F SchoppmannUNKNOWN Austrian Breast and Colorectal Cancer Study Group
Sep 21, 2004·Oncogene·Muhammad Al-Hajj, Michael F Clarke
Oct 7, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Kimberly L DumoffGeza Acs
Oct 30, 2004·International Journal of Cancer. Journal International Du Cancer·Ester Martín-VillarMiguel Quintanilla
Apr 23, 2005·The Journal of Pathology·Panayiotis A KyzasDimitrios Stefanou
Nov 10, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ilse Van der AuweraPeter B Vermeulen
Jan 10, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Andres A RomaMing Zhou
Feb 24, 2006·Virchows Archiv : an International Journal of Pathology·Pin LiangTakafumi Tabuchi
Mar 11, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Kimberly L DumoffGeza Acs
Oct 19, 2006·Journal of Cell Science·Ester Martín-VillarMiguel Quintanilla
Dec 21, 2006·British Journal of Cancer·A Wicki, G Christofori
Jan 11, 2007·Proceedings of the National Academy of Sciences of the United States of America·M E PrinceL E Ailles
Apr 24, 2007·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Fumi OhnoKenichi Kurita
Nov 18, 2008·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·D ZhaoM Xuan
Feb 14, 2009·International Journal of Radiation Oncology, Biology, Physics·Laurenz VormittagBoban M Erovic
Aug 18, 2009·Cancer Science·Yoshihisa ShimadaAtsushi Ochiai
Mar 4, 2010·Molecular Cancer·Juan P RodrigoJuana García-Pedrero
Apr 16, 2010·Virchows Archiv : an International Journal of Pathology·Matthias KreppelJoachim E Zöller
Jul 10, 2010·The American Journal of Pathology·Leah N CueniMichael Detmar
Aug 4, 2010·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Binh Y GoldsteinZuo-Feng Zhang
Nov 26, 2010·International Journal of Cancer. Journal International Du Cancer·Gerhard Frank HuberHolger Moch
May 27, 2011·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Akinori FunayamaTakashi Saku
Apr 13, 2012·Applied Immunohistochemistry & Molecular Morphology : AIMM·Sílvia Ferreira de SousaMaria Cássia Ferreira de Aguiar
Mar 12, 2013·Oral Oncology·Juan Carlos de VicenteJuana María García-Pedrero

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Citations

Jan 21, 2016·Oral Diseases·Luís Silva MonteiroSaman Warnakulasuryia
Sep 16, 2016·Clinical Oral Investigations·Agnes AssaoDenise Tostes Oliveira
Oct 27, 2017·PloS One·Jennifer K GrenierAndrew D Miller
Jan 10, 2018·BMC Cancer·Francisco Bárbara Abreu BarrosDenise Tostes Oliveira
Oct 24, 2019·Journal of Clinical Medicine·Juan C de VicenteJuana M García-Pedrero
May 26, 2020·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Fernanda Weber MelloElena Riet Correa Rivero
Nov 26, 2020·Brazilian Dental Journal·Larissa Santos Amaral RolimLeão Pereira Pinto
Jul 21, 2016·World Journal of Otorhinolaryngology - Head and Neck Surgery·Kyle P McMullenKris R Jatana

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