Expression of PRL proteins at invasive margin of rectal cancers in relation to preoperative radiotherapy

International Journal of Radiation Oncology, Biology, Physics
Asa R WallinXiao-Feng Sun

Abstract

PRL-3 (phosphatase of regenerating liver) is involved in metastasis of colorectal cancer; however, its therapeutic implication in cancer patients has not been studied. We investigated the relationships of PRL expression to radiotherapy (RT) in rectal cancer patients. Phosphatase of regenerating liver expression was immunohistochemically examined in distant (n = 36) and adjacent (n = 82) normal mucosa, primary tumor (n = 125), biopsy specimens (n = 96), and lymph node metastasis (n = 30) from rectal cancer patients participating in a clinical trial of preoperative RT. Phosphatase of regenerating liver expression was increased from the distant to adjacent mucosa and to the primary tumor (p < 0.05). PRL was highly expressed at the invasive margin in 28% of the primary tumors and 26% of the metastases. In the RT group, strong PRL expression at the invasive margin was related to distant recurrence (p = 0.006) and poor survival (p = 0.01), but not in the non-RT group. The survival significance remained even after adjusting for Dukes' stage and differentiation (p = 0.02). Additional multivariate analyses showed that the correlation with prognostic significance of PRL differed between the RT and non-RT groups (p = 0.01). Phosphatase of...Continue Reading

References

Jun 1, 1994·Molecular and Cellular Biology·R H DiamondR Taub
Apr 1, 1997·Current Opinion in Cell Biology·B G Neel, N K Tonks
Jan 27, 2000·Cell·T Hunter
Aug 17, 2000·JAMA : the Journal of the American Medical Association·C CammàM Cottone
Oct 13, 2001·Science·S SahaB Vogelstein
Jul 21, 2004·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Upik Anderiani MiskadHiroshi Yokozaki
Oct 7, 2004·Cancer Biology & Therapy·Jason A SagerAlberto Bardelli
Nov 3, 2004·Cancer Research·Belinda S ParkerStephen L Madden
Nov 10, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hirotaka KatoHiroshi Yokozaki
Feb 22, 2005·Neoplasia : an International Journal for Oncology Research·Jingfang GaoXiao-Feng Sun

❮ Previous
Next ❯

Citations

Apr 12, 2013·PloS One·Krystle T PagariganLeslie J Saucedo
Jun 9, 2009·Journal of Cancer Research and Clinical Oncology·Daniella PfeiferXiao-Feng Sun
Mar 18, 2009·International Journal of Radiation Oncology, Biology, Physics·Per LoftåsXiao-Feng Sun
Feb 25, 2009·Histopathology·Xiaofang XingChengchao Shou
Apr 23, 2016·Radiation Oncology Journal·Per LoftasOlof Hallbook
May 28, 2015·Scientific Reports·Mo-Jin WangXiao-Feng Sun
Oct 18, 2020·Journal of Personalized Medicine·Yugang WenXiao-Feng Sun
May 3, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lie YangXiao-Feng Sun

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Federica PolatoMassimo Broggini
Annals of Oncology : Official Journal of the European Society for Medical Oncology
L WangChengchao Shou
Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology
Upik A MiskadHiroshi Yokozaki
© 2022 Meta ULC. All rights reserved