Expression of programmed cell death-ligand 1 and its correlation with clinical outcomes in gliomas

Oncotarget
Jing ZengSu-Xia Lin

Abstract

Programmed cell death-ligand 1(PD-L1) was expressed in various malignancies, and interaction with its receptor programmed cell death 1 (PD-1) often contributed to immune evasion of tumor cells. In this study, we explored the expression of PD-L1 and its correlation with clinical outcomes in gliomas. Clinicopathological data of 229 patients with gliomas was collected. PD-L1 expression was assessed by tissue-microarray-based immunohistochemistry. Over 5% of tumor cells with cytoplasm or membrane staining was defined as PD-L1 positive expression. The associations of clinicopathological features with overall survival (OS) and disease-free survival (DFS) were analyzed by univariate analysis and multivariate analysis was further performed by Cox regression model. PD-L1 positive expression was observed in 51.1% gliomas patients and no significant association was verified between PD-L1 expression and pathological grade in 229 gliomas patients. However, PD-L1 expression rate was 49.2%, 53.7% and 68.8% for grade II, III and IV in 161 patients with those ≥ 12 months of OS, respectively. Although no significant discrepancies was displayed, there was a certain degree of differences between PD-L1 expression and pathological grade (49.2% vs. 5...Continue Reading

References

Mar 18, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A A BrandesM V Fiorentino
Jan 14, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jannik N AndersenNiels Peter H Møller
May 4, 2004·Nature Reviews. Immunology·Lieping Chen
Sep 2, 2004·Nature Medicine·Drew Pardoll, James Allison
Mar 11, 2005·The New England Journal of Medicine·Monika E HegiRoger Stupp
Jun 24, 2005·Neuroreport·Rick WilmottePierre-Yves Dietrich
Apr 7, 2007·Journal of Immunotherapy·Dallas B Flies, Lieping Chen
May 23, 2007·Neurology·Patrick Y Wen, Lisa M DeAngelis
Jul 10, 2007·Acta Neuropathologica·David N LouisPaul Kleihues
May 27, 2008·Nature Reviews. Immunology·Weiping Zou, Lieping Chen
Dec 31, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Teri N KreislHoward A Fine
Feb 18, 2010·Proceedings of the National Academy of Sciences of the United States of America·Michael A CurranJames P Allison
Apr 29, 2010·Current Neurology and Neuroscience Reports·Nader Pouratian, David Schiff
Jun 5, 2012·The New England Journal of Medicine·Suzanne L TopalianMario Sznol
Jun 5, 2012·The New England Journal of Medicine·Julie R BrahmerJon M Wigginton
Feb 21, 2013·Expert Opinion on Biological Therapy·Omid Hamid, Richard D Carvajal
Mar 13, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Raoul A DroeserLuigi Tornillo
Jun 4, 2013·The New England Journal of Medicine·Jedd D WolchokMario Sznol
Aug 9, 2013·OncoTargets and Therapy·Arlhee Diaz-Miqueli, Giselle Saurez Martinez
Aug 30, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yawei LiuShohreh Issazadeh-Navikas
Oct 23, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeffrey S WeberY Ann Chen
Nov 10, 2013·Cancers·Brian J AhnHideho Okada
Nov 13, 2013·Laboratory Investigation; a Journal of Technical Methods and Pathology·Vamsidhar VelchetiDavid L Rimm
Apr 10, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Janis M TaubeRobert A Anders
Apr 20, 2014·Journal of the American Academy of Dermatology·Junna ObaMasutaka Furue
May 21, 2014·Breast Cancer Research and Treatment·S MuenstS D Soysal
Jun 14, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Aaron Scott MansfieldEugene D Kwon
Nov 11, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Hidenobu IshiiTomoaki Hoshino
Nov 27, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hideho OkadaFrank S Lieberman
Dec 9, 2014·Pharmacogenomics and Personalized Medicine·Parisa Momtaz, Michael A Postow
May 1, 2015·OncoTargets and Therapy·Qun-Ying YangZhong-Ping Chen

❮ Previous
Next ❯

Citations

Jul 17, 2016·Medical Oncology·Semra PaydasGulfiliz Gonlusen
Jul 22, 2017·Biochemical and Biophysical Research Communications·Haiping Shi, Shiyuan Zhang
Mar 14, 2018·Expert Review of Anticancer Therapy·Brooke L PrinzingGiedre Krenciute
Oct 5, 2016·The Journal of Urology·Sarah R OttenhofEkaterina S Jordanova
Aug 9, 2017·Current Treatment Options in Oncology·Russell MaxwellMichael Lim
Nov 18, 2017·Journal of Neuro-oncology·Kyu Sang LeeGheeyoung Choe
Jan 27, 2019·Journal of Pediatric Hematology/oncology·Hamza S GorsiJohn R Crawford
Oct 6, 2017·Oncotarget·Paolo D'ArrigoSimona Romano
Aug 21, 2019·Nature Communications·Zachary J ReitmanRameen Beroukhim
Aug 31, 2020·Expert Review of Clinical Pharmacology·Patrick C GedeonJohn H Sampson
May 31, 2019·Journal for Immunotherapy of Cancer·Vidyalakshmi ChandramohanDarell D Bigner
Sep 29, 2020·Expert Review of Anticancer Therapy·Alessia PellerinoRiccardo Soffietti
Jan 29, 2019·Frontiers in Pharmacology·Ruo Qiao ChenXiao Qian Chen
Jul 3, 2016·Journal of Molecular Neuroscience : MN·Zhuo XiYunhui Liu
Apr 9, 2017·Journal of Hematology & Oncology·Song XueJinming Yu
Feb 20, 2019·Journal of Experimental & Clinical Cancer Research : CR·Xin WangJinming Yu
Oct 19, 2019·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Prerana JhaVaishali Suri
Feb 14, 2021·International Immunopharmacology·Abolfazl MaghrouniAmirhossein Sahebkar
Jul 9, 2021·International Journal of General Medicine·Zhuo XiTianda Feng
Sep 18, 2021·Neuropathology and Applied Neurobiology·Gayaththri Vimalathas, Bjarne Winther Kristensen
Oct 14, 2021·Journal of Pathology and Translational Medicine·Dina Mohamed El SammanHoda Hassan Abou Gabal

❮ Previous
Next ❯

Methods Mentioned

BETA
surgical resection

Software Mentioned

SPSS

Related Concepts

Related Feeds

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis