PMID: 11912284Mar 26, 2002Paper

Expression of prolactin-releasing peptide and its receptor in the human decidua

Molecular Human Reproduction
Fernando M ReisAnna M Di Blasio

Abstract

Human decidua and decidualized endometrial cells produce prolactin (PRL). Several growth factors and cytokines have been shown to regulate decidual PRL release, but a specific PRL-releasing substance remains to be characterized. Prolactin-releasing peptide (PrRP) is a peptide isolated from the brain and distinguished by its potent and specific stimulation of PRL release by cultured pituitary cells. Here, we demonstrate that human decidua expresses immunoreactive PrRP as well as the mRNAs encoding PrRP and its receptor. First trimester deciduas were obtained from women undergoing elective termination of pregnancy. Tissue specimens were stained by immunohistochemistry using a rabbit anti-human PrRP-31 antibody, and PrRP was localized in both epithelial cells of the decidual glands and in stromal cells, with diffuse distribution and no special relation with the neighbourhood of blood vessels. In primary cultures of decidual stromal cells, PrRP and PrRP receptor gene expression were detected using RT-PCR, and the identity of the PCR products was further confirmed by restriction enzyme digestion. The effect of PrRP on decidual PRL release was also evaluated, and there was a significant increase in PRL production (135 +/- 4% of contr...Continue Reading

Citations

Jan 6, 2006·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Rie KawaguchiTadao Tanaka
Apr 5, 2013·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·W LiT C Li
Sep 18, 2004·American Journal of Reproductive Immunology : AJRI·Debora LattuadaAnna M Di Blasio
Nov 27, 2014·Frontiers in Endocrinology·Tetsuya Tachibana, Tatsuya Sakamoto
Apr 6, 2007·Molecular Reproduction and Development·Daisuke KomatsuKatsuhiko Takahashi
Mar 6, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Maija-Liisa NieminenPertti Panula
Apr 4, 2014·Molecular Endocrinology·Robert J Marano, Nira Ben-Jonathan
Jun 29, 2012·The Journal of Reproduction and Development·Koji Yoshinaga
Oct 21, 2018·Hormones : International Journal of Endocrinology and Metabolism·Gabriel Levin, Amihai Rottenstreich
Oct 28, 2019·International Journal of Molecular Sciences·Veronika PražienkováLenka Maletínská
Dec 27, 2008·The Journal of Investigative Dermatology·Kerstin FoitzikRalf Paus

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