PMID: 9557786Apr 29, 1998Paper

Expression of proliferating cell nuclear antigen (PCNA) and apoptosis related antigen (LeY) in epithelial skin tumors

The American Journal of Dermatopathology
T TsujiY Koashi

Abstract

We semiquantitatively analyzed expression of PCNA and LeY in seborrheic keratosis (SK), actinic keratosis (AK), Bowen's disease (BD), and squamous cell carcinoma (SCC), using immunocytochemically stained tissue sections. PCNA expression increased in a stepwise fashion from low levels in normal skin to higher expressions within SK, AK, BD, and SCC. The levels of LeY protein also increased in this order. The PCNA expression pattern shifted from expression limited to the basal and suprabasal cell layers (in normal skin and SK) to expression extending to the upper squamous and granular layers (in AK, BD, and SCC). On the other hand, the pattern of LeY expression shifted from the granular (in normal skin) to the upper squamous (in SK and AK) and suprabasal layers (in BD and SCC). These findings suggest that PCNA expression is related to the degree of cell proliferation and that LeY expression is related to the degree of differentiation or keratinization of tumor cells. In addition, PCNA and LeY show a reciprocal relationship in their expression.

References

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Citations

Jul 20, 2007·Nucleic Acids Research·Jennifer R Schultz-NortonAnn M Nardulli
Apr 12, 2001·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·J Le PenduM Clément
Oct 2, 2007·Dermatologic Clinics·Yalçin TüzünRonni Wolf
Nov 3, 2010·International Journal of Dermatology·Metin KarakokN Emrah Koçer
Jul 2, 2015·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Giulia OttavianiL Maximilian Buja

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