PMID: 8943777Oct 1, 1996Paper

Expression of prostaglandin G/H synthase-1 and -2 in ovine amnion and placenta following glucocorticoid-induced labour onset

The Journal of Endocrinology
W J McLarenG Rice

Abstract

Parturition in the sheep is preceded by an increase in the synthesis of prostaglandins by intrauterine tissues. Prostaglandin G/H synthase (PGHS) is the central enzyme involved in prostanoid production. Its expression is enhanced during late gestation in the ewe. Recent studies have identified two PGHS isozymes, termed PGHS-1 and PGHS-2. The labour-associated expression of the two isozymes of PGHS in the sheep has not been characterized. This study investigated the changes in expression of immunoreactive PGHS-1 and PGHS-2 in ovine amnion and placenta following glucocorticoid-induced labour. Ewes underwent surgery to implant fetal and maternal vascular cannulae and uterine electromyogram electrodes between 118 and 125 days of gestation. Fetal sheep were administered either the glucocorticoid betamethasone (n = 5) or saline (control n = 6) by direct transabdominal intrafetal injection. Ewes from the betamethasone-injected group were killed in the first stage of labour as indicated by uterine electromyographic activity. Ewes from the saline-injected group were killed at the same time to obtain age-matched control tissue. The time taken to euthanasia following induced-labour onset in the glucocorticoid-injected animals was 56.6 +/-...Continue Reading

Citations

Aug 23, 2008·Molecular Biology and Evolution·Justin C HavirdDavid H Evans
Aug 24, 2002·Biology of Reproduction·R L MartinJ R G Challis
Feb 28, 2003·Biology of Reproduction·Peta L GrigsbyGraham Jenkin
Dec 17, 2004·Biology of Reproduction·Hannah K PalliserI Ross Young
May 23, 1998·Annual Review of Pharmacology and Toxicology·J R VaneR M Botting
Sep 10, 2010·Reproduction : the Official Journal of the Society for the Study of Fertility·S E KirkupD R E Abayasekara
Jul 24, 1998·Annals of Medicine·W Gibb
Apr 5, 2005·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M F AzariS S Cheema
Jun 1, 1997·Seminars in Arthritis and Rheumatism·J R Vane, R M Botting
Jul 24, 2004·Animal Reproduction Science·G Jenkin, I R Young
Nov 24, 2005·Journal of the Society for Gynecologic Investigation·Hannah K PalliserI Ross Young
May 15, 2002·American Journal of Physiology. Endocrinology and Metabolism·Laura NardoHazel H Szeto

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