Expression of prostate-specific antigen (PSA) and human glandular kallikrein 2 (hK2) in ileum and other extraprostatic tissues

International Journal of Cancer. Journal International Du Cancer
A Y OlssonA Lundwall

Abstract

Prostate-specific antigen (PSA) is a widely used marker for prostate cancer. In the literature, there are reports of nonprostatic expression of PSA that potentially can affect early diagnosis. However, the results are scattered and inconclusive, which motivated us to conduct a more comprehensive study of the tissue distribution of PSA and the closely related protein human glandular kallikrein 2 (hK2). RT-PCR, in situ hybridization and immunohistochemistry were used to detect expression of both PSA and hK2 in secretory epithelial cells of trachea, thyroid gland, mammary gland, salivary gland, jejunum, ileum, epididymis, seminal vesicle and urethra, as well as in Leydig cells, pancreatic exocrine glands and epidermis. Immunometric measurements revealed that the concentration of PSA in nonprostatic tissues represents less than 1% of the amount in normal prostate. Pronounced expression of PSA was detected in the Paneth cells in ileum, which prompted us to compare functional parameters of PSA in ileum and prostate. We found that in homogenates from these 2 tissues, PSA manifested equivalent amidolytic activity and capacity to form complexes with protease inhibitors in blood in vitro. Thus, PSA released from sources other than the pr...Continue Reading

References

Apr 20, 1987·FEBS Letters·A Lundwall, H Lilja
Oct 8, 1987·The New England Journal of Medicine·T A StameyE Redwine
Jun 1, 1994·The Journal of Clinical Endocrinology and Metabolism·J Clements, A Mukhtar
Jan 1, 1994·Breast Cancer Research and Treatment·E P DiamandisD J Sutherland
Jan 1, 1995·Journal of Clinical Laboratory Analysis·M LevesqueE P Diamandis
Aug 24, 1995·Biochemical and Biophysical Research Communications·J LövgrenA Lundwall
Feb 1, 1994·Molecular and Cellular Endocrinology·J A Clements
Feb 1, 1996·Clinical Endocrinology·J A ClementsP J Fuller
May 29, 1997·International Journal of Cancer. Journal International Du Cancer·G FrenetteJ Y Dube
Sep 23, 1997·Biochemical and Biophysical Research Communications·J LövgrenH Lilja
Nov 18, 1998·Current Opinion in Cell Biology·M JohnsenK Danø
Apr 21, 1999·International Journal of Cancer. Journal International Du Cancer·S D MikolajczykM S Saedi
Oct 8, 1999·Journal of the National Cancer Institute·A H FortierJ W Holaday
Jan 11, 2000·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·U H StenmanJ Hilgers
Jan 14, 2000·The Journal of Clinical Endocrinology and Metabolism·M MalatestaG Gazzanelli
Apr 7, 2000·Breast Cancer Research and Treatment·M H Black, E P Diamandis
Aug 26, 2000·Clinica Chimica Acta; International Journal of Clinical Chemistry·A MagklaraE P Diamandis
Feb 14, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Laila BruunAnders Christensson
Mar 6, 2003·Journal of Cancer Research and Clinical Oncology·Sandra J RoddigerRalf Kurek
Jul 15, 2003·The Prostate·Ralf KurekHans Lilja

❮ Previous
Next ❯

Citations

Apr 23, 2013·Abdominal Imaging·P J L De VisschereG M Villeirs
Jul 17, 2008·Biological Chemistry·Hannu KoistinenUlf-Håkan Stenman
May 22, 2010·AJR. American Journal of Roentgenology·Pieter J De VisschereGeert M Villeirs
Jun 27, 2014·BioMed Research International·Flavio Barchetti, Valeria Panebianco
Dec 19, 2015·International Journal of Cancer. Journal International Du Cancer·Siobhan SutcliffeElizabeth A Platz
Dec 6, 2011·Journal of the American College of Radiology : JACR·David D CasalinoRaghunandan Vikram
Sep 6, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Gert De MeerleerWilfried De Neve
Feb 1, 2008·Proteomics. Clinical Applications·Kothandaraman NarasimhanMahesh Choolani
Jan 17, 2015·Forensic Science International. Genetics·Joseph Donfack, Anissa Wiley
May 27, 2014·The Journal of Urology·Dmitry KoulikovJames L Mohler
May 18, 2016·International Journal of Urology : Official Journal of the Japanese Urological Association·Yoshiko UenoSatoru Takahashi
Dec 17, 2010·World Journal of Cardiology·Salvatore Patanè
Apr 27, 2012·The Journal of Clinical Endocrinology and Metabolism·Natalija EigelienePirkko Härkönen
Jun 20, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tomas ZimmermannHenrik Franzyk
Jan 15, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Darren R VeachDavid Ulmert

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.