Expression of protocadherin-1 (Pcdh1) during mouse development

Developmental Dynamics : an Official Publication of the American Association of Anatomists
Christoph RediesFrans Van Roy

Abstract

Protocadherin-1 (Pcdh1) is a member of the delta-protocadherin subgroup of non-clustered protocadherins. We studied the expression of Pcdh1 from the early embryonic to the adult stage of mouse development by semi-quantitative RT-PCR and in situ hybridization. Pcdh1 can be detected as early as embryonic day 9.5. In early embryogenesis, expression is especially prominent in blood vessels. During later development and in the adult mouse, organs derived from the embryonic gut, such as the esophagus, intestines, liver, lung, and submandibular gland, contain epithelia and other types of tissues that are Pcdh1-positive. Other positive organs include the brain, spinal cord, retina, peripheral ganglia, the inner ear, hair follicles, kidney, vagina, uterus, placenta, testis, prostate, and the seminal gland. The tight spatial and temporal regulation of Pcdh1 expression suggests that this protocadherin plays multiple roles not only during development but also in mature tissues and organs in the mouse.

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Citations

Dec 19, 2013·PloS One·Dinushan Nesan, Mathilakath M Vijayan
Jan 16, 2013·Gene Expression Patterns : GEP·Juntang LinChristoph Redies
Feb 4, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism· Krishna-K, Christoph Redies
Nov 22, 2011·The Journal of Comparative Neurology·Juntang LinChristoph Redies
Nov 26, 2011·Biology of Reproduction·Judith D BrownRachel J O'Neill
Oct 11, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Henk KoningGerard H Koppelman
Jul 23, 2020·Frontiers in Molecular Neuroscience·Anna PanchoEve Seuntjens
Dec 16, 2018·Cellular and Molecular Life Sciences : CMLS·Natalia Colás-Algora, Jaime Millán
Dec 22, 2010·Cell Adhesion & Migration·Soo-Young KimHyun Kim
Jul 1, 2021·Biochemistry and Biophysics Reports·Kanako FukunagaMasafumi Inui

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