Expression of protocadherin 18 in the CNS and pharyngeal arches of zebrafish embryos

The International Journal of Developmental Biology
Fumitaka KubotaHiroshi Yorifuji

Abstract

Here, we report the results of molecular cloning and expression analyses of a non-clustered protocadherin (pcdh), pcdh18 in zebrafish embryos. The predicted zebrafish pcdh18 protein shows 6566% identity and 7879% homology with its mammalian and Xenopus counterparts. It has a Disabled-1 binding motif in its cytoplasmic domain, which is characteristic of pcdh18. Zebrafish embryos expressed pcdh18 by the early gastrula stage, 6 h post-fertilization (hpf), in their animal cap but not in the germ ring or the shield. pcdh18 was expressed in the neural tube and the central nervous system (CNS) from 12 hpf. Some populations of cells in the lateral neural tube and spinal cord of 1218 hpf embryos expressed pcdh18, but expression in these cells disappeared by 24 hpf. The hindbrain of embryos at 2456 hpf expressed pcdh18 in cells closely adjacent to the rostral and caudal rhombomeric boundaries in a thread-like pattern running in the dorsoventral direction. The pcdh18-positive cells were localized in the ventral part of the hindbrain at 24 hpf and in the dorsal part from 36 hpf. pcdh18 was also expressed in the telencephalon, diencephalon, tectum, upper rhombic lip, retina and otic vesicle. Expression in the CNS decreased markedly before h...Continue Reading

Citations

Jan 16, 2013·Gene Expression Patterns : GEP·Juntang LinChristoph Redies
Jul 21, 2009·Gene Expression Patterns : GEP·Qin LiuTohru Murakami
Aug 29, 2012·Developmental Neurobiology·Yun ChenQin Liu
Nov 22, 2011·The Journal of Comparative Neurology·Juntang LinChristoph Redies
Dec 29, 2013·Molecular Biology of the Cell·Sayantanee BiswasJames D Jontes
Dec 3, 2014·Mechanisms of Development·I DuranM Marí-Beffa
Aug 10, 2010·Developmental Biology·Shunsuke TazumiHideho Uchiyama
Oct 28, 2017·Cancer Cell International·Takehiro HayashiShuichi Kaneko

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