Expression of PrP mRNA is regulated by a fragment of MRP8 in human fibroblasts

Biochemical and Biophysical Research Communications
M KniazevaV P Terranova

Abstract

Prion protein (PrPc) is expressed in many tissues, both in human and animals. The scrapie isoform of PrPc has been shown to cause neurodegeneration. In other studies it has been demonstrated that overexpression of the PrP gene can result in nonneuronal tissue degradation. Little is known, however, about the normal function of PrPc and prion protein gene regulation. Using cultured periodontal ligament cells as an experimental model, we have demonstrated the stimulation of PrP mRNA expression by MRP8 (migration inhibitory factor-related protein). Additionally, we have shown that PDGF has an opposite effect acting as a suppresser. We propose that a correlation exists between PrPc mRNA expression and cell growth arrest and differentiation.

References

Jul 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·L A Greene, A S Tischler
Dec 15, 1992·Biochemistry·S B Prusiner
Jun 14, 1991·Science·S B Prusiner
Apr 1, 1985·Cell·B OeschL E Hood
Jan 1, 1988·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·D WionP Brachet
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·W C MobleyM P McKinley
Feb 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·G J WistowP S Zelenka
Nov 15, 1993·Biochemical and Biophysical Research Communications·C LasmézasD Dormont
Mar 1, 1994·Brain Research. Molecular Brain Research·F LazariniD Dormont
Jun 30, 1994·Biochemical and Biophysical Research Communications·F AtoufP Czernichow
May 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·D A HarrisW D Snider

❮ Previous
Next ❯

Citations

Jun 26, 2002·Biological & Pharmaceutical Bulletin·Yutaka KikuchiJun-ichi Sawada
Jun 16, 2009·Brain Research Reviews·Oriol NicolasJosé A del Río
Sep 23, 2006·Virus Genes·Cai-Xia HanDe-Ming Zhao
Apr 9, 2008·Physiological Reviews·Rafael LindenRicardo R Brentani

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.