Expression of RAB27B is up-regulated in senescent human cells

Mechanisms of Ageing and Development
Michihiko FujiiDai Ayusawa

Abstract

Immortal SVts8 cells that express thermolabile SV40 T antigen exhibit a senescence-like phenomenon upon inactivation of the T antigen. By using a cDNA subtractive hybridization technique, RAB27B, a member of the RAB GTPase family, was found to be up-regulated in senescent SVts8 cells. The up-regulation of RAB27B depends on the p53 gene. Enhanced expression was also observed in replicative senescence in normal human fibroblasts.

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Citations

Mar 1, 2012·Mechanisms of Ageing and Development·Donggi PaikJoong-Jean Park
Oct 5, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Hee Woong YangJoon Kim
Mar 11, 2020·Frontiers in Cell and Developmental Biology·Jérémy BoulestreauDanièle Noël
Nov 10, 2020·Cell Biochemistry and Function·Mahdi Ahmadi, Jafar Rezaie
May 29, 2020·Mechanisms of Ageing and Development·Ryan WallisCleo L Bishop
Dec 16, 2019·Cytokine & Growth Factor Reviews·Alessandra SorianiAlessandra Zingoni

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