Expression of RANTES and CCR1 in oral lichen planus and association with mast cell migration

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
Z Z ZhaoN W Savage

Abstract

T lymphocytes and mast cells infiltrate the lamina propria in oral lichen planus (OLP). Chemokines and their receptors are involved in T cell and mast cell migration and accumulation during the inflammatory process. In the present study, we investigated the role of RANTES and its receptors in OLP using immunohistochemistry, RT-PCR and an in vitro chemotaxis assay. RANTES and CCR1 were expressed on T cells and mast cells in OLP, while OLP lesional T cell supernatants stimulated CCR1 mRNA expression in a human leukemia mast cell line (HMC-1). TNF-alpha stimulated CCR1, CCR4 and CCR5 mRNA expression in the same cell line. OLP lesional T cell supernatants stimulated HMC-1 migration, which was partly inhibited by anti-RANTES antibody. The present study shows, for the first time, the distribution of RANTES and CCR1 in OLP. It is hypothesized that RANTES and CCR1 may play important roles in mast cell trafficking and related events in OLP.

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Citations

Jul 14, 2009·International Immunology·Nimita H FifadaraSanta Jeremy Ono
Feb 14, 2012·International Journal of Rheumatic Diseases·Md Nazrul IslamJohannes J Rasker
Feb 4, 2006·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Mana IchimuraMasafumi Yamamoto
Oct 7, 2010·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·M R RoopashreeAbhilasha Shukla
Jun 15, 2005·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Giovanni LodiKobkan Thongprasom
Apr 7, 2016·Journal of Cancer Prevention·Soma Susan VargheseArun George
Aug 14, 2012·Autoimmune Diseases·Luís UvaPaulo Filipe
Aug 23, 2002·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·P B SugermanM Bigby
Jun 12, 2003·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·Laurence J Walsh
Oct 26, 2016·Molecular Medicine Reports·Juanyong XuYuan Fan

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