Expression of rat renal cortical OAT1 and OAT3 in response to acute biliary obstruction

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Anabel BrandoniAdriana M Torres

Abstract

Renal function in the course of obstructive jaundice has been the subject of great interest; however, little is known about the expression of renal organic anion transporters. The objective of this work was to study, in rats with acute extrahepatic cholestasis, the cortical renal expression of the organic anion transporter 1 (OAT1) and the organic anion transporter 3 (OAT3), in association with the pharmacokinetics and renal excretion of furosemide (FS). Male Wistar rats underwent bile duct ligation (BDL rats). Pair-fed sham-operated rats served as controls. All studies were carried out 21 hours after surgery. Rats were anesthetized and the pharmacokinetic parameters of FS and the renal elimination of FS were determined. Afterwards, the kidneys were excised and processed for immunoblot (basolateral membrane and renal homogenates) or immunocytochemical (light microscopic and confocal immunofluorescence microscopic analysis) techniques. The systemic and renal clearance of FS as well as the excreted and secreted load of FS increased in BDL rats. In kidneys from BDL rats, immunoblotting showed a significant increase in the abundance of both OAT1 and OAT3 in homogenates from renal cortex. In basolateral membranes from kidney cortex ...Continue Reading

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Citations

Jun 18, 2009·Archives of Toxicology·Gisela Di GiustoAdriana M Torres
Mar 3, 2007·Pflügers Archiv : European journal of physiology·Carsten KneuerKerstin U Honscha
Feb 25, 2010·Journal of Bioenergetics and Biomembranes·Valentina GiorgioGiovanna Lippe
Sep 18, 2008·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Gisela Di GiustoAdriana M Torres
Jan 21, 2009·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Anabel Brandoni, Adriana Mónica Torres
Oct 23, 2013·PloS One·Zhen-Meng WangWei-Feng Yu
Nov 27, 2008·World Journal of Gastroenterology : WJG·Adriana Monica Torres
Dec 1, 2012·World Journal of Gastroenterology : WJG·Anabel BrandoniAdriana Mónica Torres
Jul 6, 2014·Expert Opinion on Drug Metabolism & Toxicology·Mark J Canet, Nathan J Cherrington
Jul 31, 2012·Pharmacology & Therapeutics·Gerhard Burckhardt
Dec 2, 2006·Biochemical Pharmacology·Tomohiro Terada, Ken-ichi Inui
Aug 31, 2012·Journal of Biochemical and Molecular Toxicology·Lindsay L Yacovino, Lauren M Aleksunes
Dec 3, 2009·Biopharmaceutics & Drug Disposition·Adam L VanWertDouglas H Sweet
Jun 27, 2006·Journal of Pharmacological Sciences·Naohiko AnzaiHitoshi Endou
May 16, 2008·American Journal of Physiology. Renal Physiology·Jiarong ChenKen-ichi Inui
Dec 10, 2014·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Mark J CanetNathan J Cherrington
Mar 9, 2007·American Journal of Physiology. Renal Physiology·Ken OgasawaraKen-ichi Inui
Feb 18, 2017·Clinical Pharmacokinetics·Anton IvanyukThierry Buclin
Aug 14, 2015·World Journal of Gastroenterology : WJG·Anabel Brandoni, Adriana Mónica Torres
May 27, 2020·Pflügers Archiv : European journal of physiology·Evangelina Cecilia NosettoAnabel Brandoni
Aug 14, 2020·International Journal of Molecular Sciences·Marek DroździkAgnieszka Droździk
Nov 28, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Jiayue LiuGuixin Zhang

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