Expression of receptor beta-chain variable region by T cells in human periodontal disease

Archives of Oral Biology
Erica GemmellGregory Seymour

Abstract

T cells play a major part in the immune response in periodontal diseases. In order to determine any selective T-cell receptor (TCR) beta-chain variable region (V beta) usage in the infiltrates of healthy/ gingivitis (H/G) and adult periodontitis (AP), cells were extracted from gingival biopsies, the CD4 and CD8 cells stained with antibodies to eight V beta regions, and two-colour flow cytometry used to analyse the data. The frequencies of CD4 and CD8 cells expressing each of the TCR-V beta families varied from 0 to 46% between individuals. A high percentage of CD4 and CD8 cells expressed the V beta 13 family in several AP biopsies, but, in a number of H/G tissues, a high percentage of T cells expressed up to three families including the V beta 13 region, these varying from individual to individual. The mean results showed a significantly greater percentage of V beta 5.2-3-positive CD4 cells (p = 0.003) and V beta 5.1- and 5.2-3-positive CD8 cells (p = 0.003 and 0.025, respectively) isolated from H/G than AP tissues. The percentage of V beta 3.1-positive CD4 cells extracted from H/G tissues was also higher but not quite significant at the 0.05 level (p = 0.051). Sections of gingival tissue in biopsies from H/G and AP were staine...Continue Reading

References

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Citations

Apr 25, 2000·Journal of Periodontology·R PattniP M Bartold
Aug 9, 2003·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·Yen-Tung A Teng
Sep 1, 2005·Journal of Clinical Periodontology·Tord Berglundh, Mauro Donati
Jan 1, 1999·Oral Microbiology and Immunology·E GemmellG J Seymour

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