Expression of receptors for IgA in hairy-cell and other B-cell leukaemias

British Journal of Haematology
P M LydyardJ C Cawley

Abstract

In six cases of both hairy-cell leukaemia (HCL) and chronic lymphocytic leukaemia (CLL) it was shown that the pathological cells express receptors for the Fc portion of IgA (RFc alpha). Many of the cells simultaneously expressed receptors for IgA, IgM and IgG, and blocking studies showed that these are distinct receptors. In contrast, the malignant cell of most of the various other B-cell leukaemias studied showed low levels of RFc alpha expression. The significance of the results is briefly discussed and it is suggested that receptor expression may be a marker of certain stages of B-cell development.

References

Jan 1, 1979·American Journal of Hematology·G F BurnsF G Hayhoe
Aug 1, 1975·European Journal of Immunology·L MorettaM C Mingari
May 1, 1974·British Journal of Haematology·D A GaltonG J Goldenberg
Apr 1, 1980·The Journal of Experimental Medicine·E L ReinherzS F Schlossman
Jun 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·M W FangerG M Bernier
Mar 1, 1980·European Journal of Immunology·O Sjöberg
Jan 1, 1980·Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer·J C CawleyG J Hayhoe
Mar 1, 1981·Molecular Immunology·M W Fanger, P M Lydyard
Dec 1, 1981·Clinical Oncology·C J IngoldbyJ Spencer

❮ Previous
Next ❯

Related Concepts

Related Feeds

B cell Differentiation

Depending on the signal received through the B cell receptor and other receptors, B cells differentiate into follicular or marginal zone B cells. Here is the latest research pertaining to this differentiation process.

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.