PMID: 9650754Jul 3, 1998Paper

Expression of retinoblastoma gene product and p21 (WAF1/Cip 1) protein in gliomas: correlations with proliferation markers, p53 expression and survival

Acta Neuropathologica
P A KorkolopoulouE Thomas-Tsagli

Abstract

Using immunohistochemistry we evaluated the expression of two negative regulators of the cell cycle, the retinoblastoma gene product (pRb) and the WAF1/Cip1 gene product (p21), in consecutive paraffin sections from 54 gliomas (49 astrocytomas and 5 oligodendrogliomas) and related it to clinicopathological parameters, proliferative fraction, p53 expression and survival. Survival analysis was restricted to the group of diffuse astrocytomas (48 patients). pRb expression did not correlate with histological type, grade or p53 expression, while a moderately strong correlation existed between pRb expression and the percentages of proliferating cell nuclear antigen (PCNA) and MIB-1-positive cells. In 30% of cases we observed diminished pRb expression (i.e., a low pRb/Ki-67 ratio), irrespective of grade or histological type. p21 protein was elevated in 50% of cases, especially within the higher grades. The percentage of p21-positive cells was not related to histological type or grade but correlated loosely with PCNA and pRb expression. A p53-negative/p21-negative phenotype was characteristic of oligodendrogliomas and low-grade astrocytomas, whereas the p53-positive/p21-positive, p53-positive/p21-negative and p53-negative/p21-positive ph...Continue Reading

Citations

Sep 16, 2008·Clinical and Experimental Medicine·Tao SongJiesheng Fang
May 15, 2009·Nature Reviews. Cancer·Tarek Abbas, Anindya Dutta
Mar 19, 2002·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Mark Yen-Ping KuoChun-Pin Chiang
Feb 12, 2002·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Y UematsuK Kubo
May 2, 2003·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Tetsuya Shiraishi, Kazuo Tabuchi
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Apr 28, 2007·Proceedings of the National Academy of Sciences of the United States of America·Deepak KamnasaranAbhijit Guha
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