Expression of retinoic acid-inducible gene-I in vascular smooth muscle cells stimulated with interferon-gamma

Life Sciences
Tadaatsu ImaizumiKei Satoh

Abstract

Vascular smooth muscle cells (SMC) play an important role in atherogenesis and vasospasm. Interferon-gamma (IFN-gamma) is a potent cytokine that regulates immune and inflammatory responses by inducing multiple genes in many types of cells including SMC. Retinoic acid-inducible gene-I (RIG-I) is a putative RNA helicase, but its physiological function is not known. RIG-I is induced in leukemic cells by retinoic acid or in endothelial cells by lipopolysaccharide. We have studied the expression of RIG-I in cultured SMC from human umbilical artery. IFN-gamma stimulated SMC to express RIG-I mRNA and protein in concentration- and time-dependent manners. Immunohistochemical analysis revealed the expression of RIG-I in SMC in vivo. We conclude that RIG-I may play some pathophysiological role in immune and inflammatory reactions in SMC.

References

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Citations

Jun 1, 2011·Protein & Cell·Feng Liu, Jun Gu
Dec 24, 2010·Critical Reviews in Immunology·Tomoh Matsumiya, Diana M Stafforini
Oct 12, 2010·Reproduction : the Official Journal of the Society for the Study of Fertility·Gwonhwa SongFuller W Bazer
Aug 2, 2014·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Brian P WalcottChristopher S Ogilvy
Nov 18, 2005·Endothelium : Journal of Endothelial Cell Research·T ImaizumiK Wakabayashi
Dec 22, 2006·Journal of Dermatological Science·Hideo KitamuraKatsumi Hanada
Oct 21, 2006·Microbiology and Immunology·Tadaatsu ImaizumiKei Satoh
May 9, 2007·Journal of Atherosclerosis and Thrombosis·Tadaatsu ImaizumiKei Satoh
Jan 17, 2015·Circulation Research·Sebastian ZimmerEicke Latz
Sep 20, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tomoh MatsumiyaDiana M Stafforini
Jun 1, 2017·Journal of Cellular and Molecular Medicine·Sabine HergovitsHeike M Hermanns
Aug 6, 2019·Frontiers in Immunology·Morgan Brisse, Hinh Ly

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