PMID: 11340568May 8, 2001Paper

Expression of retinoic acid receptor gamma correlates with retinoic acid sensitivity and metabolism in head and neck squamous cell carcinoma cell lines

International Journal of Cancer. Journal International Du Cancer
I KlaassenB J Braakhuis

Abstract

Retinoids, analogues of vitamin A, can reverse premalignant lesions and prevent second primary tumors in patients with head and neck squamous cell carcinoma (HNSCC). The effects of retinoids are mediated by retinoic acid receptors (RARs) and retinoid X receptors (RXRs), which act as ligand-activated transcription factors. The regulation of cell growth, differentiation and retinoid metabolism in normal, premalignant and malignant cells by retinoids is thought to be a result of their effects on gene expression. We investigated mRNA expression of RARs (alpha, beta, and gamma) and RXR-beta by means of RNase protection and related this to retinoic acid (RA)-induced growth inhibition and RA turnover in four HNSCC cell lines (UM-SCC-14C, UM-SCC-22A, UM-SCC-35 and VU-SCC-OE). An RA-resistant subline of UM-SCC-35 was generated by exposure to increasing concentrations of RA for 8 months (designated UM-SCC-35R). RA turnover was determined on the basis of decreasing RA levels in the cells and culture medium after exposure to 1 microM RA. We found that RAR-gamma mRNA expression was strongly correlated with RA-induced growth inhibition (p = 0.016, R = 0.92) and RA turnover (p = 0.041, R = 0.86). RAR-beta transcript levels were reduced in thr...Continue Reading

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Citations

Jul 24, 2007·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Carla F M MolthoffAdriaan A Lammertsma
Aug 9, 2002·Oral Oncology·Ingeborg Klaassen, Boudewijn J M Braakhuis
Jul 23, 2005·Journal of Neurovirology·Walter RoyalReid Bissonnette
Jun 11, 2004·Annual Review of Nutrition·Dianne Robert SopranoKenneth J Soprano
Aug 20, 2003·International Journal of Cancer. Journal International Du Cancer·Yongdoo ChoiYoungro Byun
Sep 15, 2005·International Journal of Cancer. Journal International Du Cancer·Ranju RalhanSuryanaryana V S Deo
Oct 13, 2004·Mutation Research·Richard M Niles
Oct 26, 2010·Biochimica Et Biophysica Acta·Vanessa Duong, Cécile Rochette-Egly
Apr 20, 2004·Oncogene·Chang Feng ChenDavid Lohnes
Jan 12, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ezra E W Cohen, Everett E Vokes

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